In humans, SCNT was envisioned as a means of generating personalized embryonic stem cells from patients’ somatic cells, which could be used to study disease mechanisms and ultimately for cell-based therapies (Lanza et al., 1999; Yang et al., 2007). However, the derivation of human nuclear ...
Embryonic stem cellsES cell derivationHuman embryonic stem cells are commonly derived from the inner cell mass of developing blastocyst-stage embryos. They are capable of unlimited expansion in vitro and can be maintained in culture indefdoi:10.1007/978-3-319-30582-0_2Simone Aparecida Siqueira ...
Human Embryonic Stem CellsChiu, A. Y.Rao, M. S.BRITISH JOURNAL OF CANCER
Human embryonic stem (hES) cells are derived from theinner cell massof the 5-6 day embryonicblastocyst. These cells have the ability to self-renew and they are pluripotent, meaning that they have the ability to become any cell type in the primarygerm layers(ectoderm,mesoderm, or endoderm) (...
Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer For the first time, diploid human embryonic stem cells are derived from somatic cell nuclear transfer. M Tachibana,P Amato,M Sparman,... - 《Cell》 被引量: 702发表: 2013年 Derivation of Pre-X Inactivation Human Embryonic ...
Here we show that transplantation of ∼750 million cryopreserved human embryonic stem cell–derived cardiomyocytes (hESC-CMs) enhances cardiac function in macaque monkeys with large myocardial infarctions. One month after hESC-CM transplantation, global left ventricular ejection fraction improved 10.6 ...
Human embryonic stem cells (hESCs) hold enormous promise for regenerative medicine. Typically, hESC-based applications would require their in vitro differe... W Li,W Sun,Y Zhang,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 414发表: 2011...
细胞Human胚胎干细胞humanstemStemCells人类胚胎干细胞cells 系统标签: 干细胞cellsembryonichumanstem胚胎 MINI-REVIEWHUMANEMBRYONICSTEMCELLSINTRODUCTIONHumanembryonicstemcells(hESCs)arederivedfrompre-implantationblastocysts1andretaintheremarkableabilitytodifferentiateintomultipledifferenttissues2andtoself-renewthispropertyinvitr...
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. While subpopulations of h... FW King,C Ritner,W Liszewski,... - 《Stem Cells & Development》 被引量: 80发表: 2009年 Differentiation of Human Embryonic Stem Cells ...
Human embryonic stem cells (ESCs) maintain their pluripotency through a variety of molecular signaling pathways. Extracellular proteins like PDGF, Neurotrophins, FGF, BMPs, and WNT regulate signaling cascades leading to stem cell renewal or differentiation. For example, signaling through BMPs activates ...