Cells were left untreated or treated with trametinib (3 nM) or the combination of dabrafenib (80 nM) and cetuximab (1 µg ml−1), and cell proliferation was monitored using an incucyte. Data represent the mean ± s.d. of biological triplicates and are representative of ...
Prostate adenocarcinoma (PRAD) persists as the predominant non-cutaneous malignancy diagnosed in males, which is a primary contributor to cancer-related mortality globally. It is reported that the progression of prostate adenocarcinoma is associated with
It enables the relative similarity and dissimilarity, between target and source molecules, for both the analogue and category approaches, to be analysed and provides a basis for alternative scenarios such as read-across based on formation of a common metabolite or biological profile to be defiend....
PhenoGraph (Levine et al., 2015) and t-SNE analysis using the R package ‘CyTOFkit’ (Chen et al., 2016) were performed to classify and visualize the subpopulations of tumor-infiltrating lymphocytes (TILs) based on the cell surface and intracellular markers listed in the Key Resources Table....
Cells were left untreated or treated with trametinib (3 nM) or the combination of dabrafenib (80 nM) and cetuximab (1 µg ml−1), and cell proliferation was monitored using an incucyte. Data represent the mean ± s.d. of biological triplicates and are representative of ...
that can be found in urine as a potential source for diagnosing PD. These tiny packages contain different kinds of molecules from inside the cells. We analyzed urine samples from 138 individuals and found several proteins involved in PD development that could be biological indicators for early dete...
that can be found in urine as a potential source for diagnosing PD. These tiny packages contain different kinds of molecules from inside the cells. We analyzed urine samples from 138 individuals and found several proteins involved in PD development that could be biological indicators for early dete...
(Fig.3A). Although the clustering result based on gene expression data can also classify the tumor and normal cells into different clusters, it did not capture the pattern of C3 being positioned in-between the normal cell cluster C5 and other tumor cell clusters (Fig.S5B). Indeed, compared...
Vesicles in the size range of the filter pore sizes are observed in the LEV (0.8 μm), MEV (0.22 μm) and SEV (0.02 μm) fractions. Scale bars: 500 nm; SEV inset: 25 nm. TEM was repeated at least twice on biological replicates from a mouse EGFR WT primary GBM culture. (F) ...