the effect potency10,11,12,13,14,15. Surprisingly, none of them addresses the obvious question of whether the observed curve constitutes a significant regulation or is simply the result of experimental error. Assessing the significance of the regulation is especially relevant for applications...
The concept behind drug repurposing is simple and relies on the fact that drug molecules often interact with multiple biological targets. In this framework, the observed therapeutic/side effects of a typical drug molecule result from the collective pharmacological footprints generated from these interactio...
One of the most successful approaches to develop new small molecule therapeutics has been to start from a validated druggable protein target. However, only a small subset of potentially druggable targets has attracted significant research and development resources. The Illuminating the Druggable Genome (...
we present an approach to classify the three domains of life using topological information about the underlying metabolic networks. These networks have been shown to share domain-independent structural similarities, which pose a special challenge for our endeavour. We ...