DEAD-box RNA helicases are important players in eukaryotic and bacterial RNA metabolism. A helicase from Staphylococcus aureus was recently shown to affect RNA decay, most likely via its interaction with the proposed Gram-positive degradosome. Some, but not all, RNAs are stabilized when the ...
3.1.1DEAD-box RNA helicases The majority of all proteins identified as components ofRNPgranules in oocytes contain RNA-binding domains, and several DEAD-boxRNAhelicases localize to oocyte RNPs.DEAD-box RNA helicasesmay perform generally in large RNP particles as RNA chaperones or architectural fact...
DEAD-box RNA helicases are involved in various aspects of RNA metabolism, including RNA transcription, premRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation and RNA decay. DEAD-box RNA解旋酶参与RNA转录、前体mRNA剪切、核糖体发生、核质运输、蛋白质翻译、RNA降解等重要的生命活动。
To identify host factors relevant for MYXV tropism in human cancer cells, we performed a small interfering RNA (siRNA) library screen targeting the 58 human DEAD-box RNA helicases in two permissive human cancer cells (HeLa and A549), one semi-permissive (786-0), and one nonpermissive cell ...
DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic proto
DEADboxRNAhelicasefunctionsincancer FrancesV.Fuller-Pace Divisiono,CancerResearch;Universityo,Dundee;NinewellsHospitalandMedicalSchool;Dundee,Scotland Keywords:DEADbox(multi)unctionalRNAhelicases(cancer)oncogene,tumorsuppressor Memberso,theDEADbox,amilyo,RNAhelicasesareknowntobeinvolvedinmostcellularprocessesthatrequi...
The review summarizes a current knowledge about a role of RNA helicases in the development and maintenance of gamenogenesis in eukaryotes. We focused on th
《Rna-a Publication of the Rna Society》Charette JM, Baserga SJ. The DEAD-box RNA helicase-like Utp25 is an SSU processome component. RNA. 2010; 16 :2156–2169.Charette, J. M. & Baserga, S. J. The DEAD-box RNA helicase-like Utp25 is an SSU proces...
DEAD-box RNA解旋酶(DEAD-box helicase, DDX)是一类ATP依赖的RNA解旋酶,其功能是调控RNA代谢的各个方面,包括转录、剪切、转出、翻译、核糖体合成及miRNA调控,进而参与肿瘤增殖、肿瘤凋亡、肿瘤侵袭和转移、肿瘤耐药和肿瘤免疫治疗等多种过程。DDX21是DDX家族蛋白重要成员,可在多种肿瘤组织中异常表达,对肿瘤的发生、...
RNA helicases of the DEAD-box protein family all have nine characteristic motifs. These motifs clearly distinguish this family from other, highly related, RNA helicase families such as the DEAH-box or the Ski2 families. The motifs are contained within a core domain that is flanked by less-co...