DEAD-box RNA HelicasesDDX3, a DEAD-box RNA helicase, binds to the hepatitis C virus (HCV) core protein. However, the role(s) of DDX3 in HCV replication is still not understood. Here we demonstrate that the accumulation of both genome-length HCV RNA (HCV-O, genoty...
DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoanLeishmania.We show that genetic inactivatio...
DEAD-box RNA解旋酶(DEAD-box helicase, DDX)是一类ATP依赖的RNA解旋酶,其功能是调控RNA代谢的各个方面,包括转录、剪切、转出、翻译、核糖体合成及miRNA调控,进而参与肿瘤增殖、肿瘤凋亡、肿瘤侵袭和转移、肿瘤耐药和肿瘤免疫治疗等多种过程。DDX21是DDX家族蛋白重要成员,可在多种肿瘤组织中异常表达,对肿瘤的发生、...
2. Linder P, Jankowsky E. From unwinding to clamping - the DEAD box RNA helicase family. Nat Rev Mol Cell Biol. 2011;12(8):505-516. 3. Yang YC, Chiang CW, Yeh CT et al. DDX56 modulates the translation of cell-cycle-associated proteins and upregulates the expression of nucleophosmin...
Over the last 3 decades, the DEAD-box RNA helicase (RH) family proteins have been isolated from a wide range of organisms from viruses to E. coli to humans [1]. Their mechanisms of action, functional diversity, regulation and potential targets for disease treatment have gradually emerged over...
(3'-UTR) of HCV RNA, and plays important role in the initiation of HCVRNA replication[81]. DEAD-box helicases can interact with virus elements and proteins, to help viralRNA splicingand subcellular exporting. For example, DDX1 binds to HIV Rev-response element (RRE) to form RNA complexes...
(III—I)promoter,as well as NFkB responsive reporter activity during DENV infection.Conclusions:Overall,our data imply that DDX3X,a member of DEAD-box RNA helicase,is necessary for IFN production and could inhibit DENV replication.DDX3X promotes the production of IFN-βduring DENV infection ...
DEAD Box Polypeptide 5 (DDX5) Antibody供应商 Abbexa产品货号 abx136160产品报价 ￥询价/80ul ￥询价/400ul产品说明书 点击查看购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。产品新闻背景资料 DDX5 is putative RNA helicases. The protein is implicated in ...
RNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism including RNA synthesis, processing and degradation. The function and mechanism of action of most of these helicases in animal development and human disease are largely unexplored. ...
The genetic regulation of cell cycle progression and cell proliferation plays a role in the growth of non-small cell lung cancer (NSCLC), one of the most common causes of cancer-related mortality. Although DEAD-box RNA helicases are known to play a role in cancer development, including lung...