Kinetics of the De Novo NAD/NADH Pathway from AKI to CKDdoi:10.1681/ASN.20233411S1120aJustine SerreINSERM UMRS 1155, Paris, France;Alexandre BrasINSERM UMRS 1155, Paris, France;Pierre GalichonINSERM UMRS 1155, Paris, France;Juliette Hadchouel...
raising interest in its impact on human health. De novo NAD+biosynthesis from tryptophan is evolutionarily conserved yet considered supplanted among higher species by biosynthesis from nicotinamide (NAM). Here we show that a bottleneck enzyme in de novo biosynthesis, quinolinate phosphoribosyltransferase ...
burnetii nadB mutant with a plasmid expressing this inactive R275L NadB failed to restore replication to WT levels, confirming the link between de novo NAD synthesis and intracellular replication of C. burnetii. This suggests that targeting this prokaryotic-specific pathway could advance the ...
Despite the use of Hymenolepis diminuta as a model organism in experimental parasitology, a full genome description has not yet been published. Here we present a hybrid de novo genome assembly based on complementary sequencing technologies and methods. T
An evolutionary analysis of enzymes catalyzing de novo NAD+ biosynthesis resulted in evolutionary trees incongruent with established organismal phylogeny, indicating numerous gene transfers. Endosymbiotic gene transfers probably introduced the aspartate pathway into eukaryotes and may have distributed it among ...
thede novoassembly of complex plant mt genomes is challenging. PacBio HiFi sequencing integrates the advantages of high precision and long read lengths and is becoming the “gold” standard for thede novoassembly of plant mt genomes [54]. Herein, we completed the mt assembly for pepino using ...
et al. De-novo assembly of mango fruit peel transcriptome reveals mechanisms of mango response to hot water treatment. BMC Genomics 15, 957 (2014). https://doi.org/10.1186/1471-2164-15-957 Download citation Received13 February 2014 Accepted23 October 2014 Published05 November 2014 DOIhttps://...
5). Based on the de novo assembly and annotation of the Sacha Inchi transcriptome, a total of 89 transcripts were identified as candidate unigenes for 4 enzymes of fatty acid catabolism pathway, including 27 unigenes encoding long-chain acyl-CoA synthetase (LACS) that catalyzes initial reactions...
Pathway 4A identified by novoStoic is a five-step pathway of bdo synthesis that recapitulates the downstream pathway of Yim et al.35(Fig.4, steps 1–5). This pathway converts succoa into bdo with a concomitant oxidation of four NAD(P)H and production of two co-enzyme A (coa) molecules...