burnetii nadB mutant with a plasmid expressing this inactive R275L NadB failed to restore replication to WT levels, confirming the link between de novo NAD synthesis and intracellular replication of C. burnetii. This suggests that targeting this prokaryotic-specific pathway could advance the ...
Kinetics of the De Novo NAD/NADH Pathway from AKI to CKDdoi:10.1681/ASN.20233411S1120aJustine SerreINSERM UMRS 1155, Paris, France;Alexandre BrasINSERM UMRS 1155, Paris, France;Pierre GalichonINSERM UMRS 1155, Paris, France;Juliette Hadchouel...
Pathway 4A identified by novoStoic is a five-step pathway of bdo synthesis that recapitulates the downstream pathway of Yim et al.35(Fig.4, steps 1–5). This pathway converts succoa into bdo with a concomitant oxidation of four NAD(P)H and production of two co-enzyme A (coa) molecules...
Nicotinamide adenine dinucleotide (NAD+) extends longevity in experimental organisms, raising interest in its impact on human health. De novo NAD+ biosynthesis from tryptophan is evolutionarily conserved yet considered supplanted among higher species by
Although de novo NAD+ biosynthesis is essential, different metabolic pathways exist in different eukaryotic clades. The kynurenine pathway starting with tryptophan was most likely present in the last common ancestor of all eukaryotes, and is active in fungi and animals. The aspartate pathway, detected...
Ishida S, Takabayashi A, Ishikawa N, Hano Y, Endo T, Sato F: A novel nuclear-encoded protein, NDH-dependent cyclic electron flow 5, is essential for the accumulation of chloroplast NAD(P)H dehydrogenase complexes. Plant Cell Physiol. 2009, 50 (2): 383-393. Article CAS PubMed Google ...
5). Based on the de novo assembly and annotation of the Sacha Inchi transcriptome, a total of 89 transcripts were identified as candidate unigenes for 4 enzymes of fatty acid catabolism pathway, including 27 unigenes encoding long-chain acyl-CoA synthetase (LACS) that catalyzes initial reactions...
Fig. 1: OGT regulates nucleotide synthesis and NAD production. a, The scheme of PRPS-catalyzed reaction showing the metabolic pathway of de novo synthesis of nucleotides and NAD production from glucose-derived pentose phosphate pathway.b,c, H1299 cells were transfected with the indicated siRNAs and...
Despite the use of Hymenolepis diminuta as a model organism in experimental parasitology, a full genome description has not yet been published. Here we present a hybrid de novo genome assembly based on complementary sequencing technologies and methods. T