Impact of low-lipid environment on de novo lipid synthesis pathways in cancer cellsdoi:10.1186/2051-1426-3-S2-P424Nousheen ZaidiUniversity of the PunjabJournal for ImmunoTherapy of Cancer
Cancer Cells Differentially Activate and Thrive on De Novo Lipid Synthesis Pathways in a Low-Lipid Environment Veerle W. Danie¨ ls1, Karine Smans2, Ines Royaux2, Melanie Chypre2, Johannes V. Swinnen1., Nousheen Zaidi1,2,3*. 1 KU Leuven – University of Leuven...
We demonstrate that FASN, the rate-limiting enzyme in FA synthesis, while being dispensable in EGFR-mutant or wild-type KRAS LC, is required for the viability of KMLC cells. Integrating lipidomic, transcriptomic and functional analyses, we demonstrate that FASN provides saturated and monounsaturated...
These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes inde novofatty-acid synthesis and related pathways.关键词: lipid metabolism fatty-acid synthase acyl-CoA synthetase ...
We observed that in vitro growth of Mtb is dependent on de novo synthesis of histidine, as histidine supplementation is essentially required when the biosynthesis pathway is disrupted. However, the scenario is interestingly different in an in vivo mouse model of infection. We find that 2 weeks ...
They are synthesized de novo via a common backbone (sphinganine) that is modified to produce ceramides and more complex phospho- and glycosphingolipids. This minireview summarizes sphingoid base metabolism, function, and perturbation, including the participation of de novo sphingolipid biosynthesis in...
(1983). Lipid composition and de novo lipid biosynthesis of human palmar fat in Dupuytren's disease. Lipids 18: 371-374.Rabinowitz JL, Ostermann JR, Bora FW, Steffer J (1983) Lipid composition and de novo lipid biosynthesis of hu- man palmar fat in Dupuytren's disease. Lipids 18:371- ...
Recycling of the major thylakoid lipid MGDG and its role in lipid homeostasis in Chlamydomonas reinhardtii. Plant Physiol. 2021;187:1341–1356. Article PubMed PubMed Central CAS Google Scholar Riccio G, De Luca D, Lauritano C. Monogalactosyldiacylglycerol and sulfolipid synthesis in microalgae. ...
cholesterol metabolism is a broad property of phylogenetically diverse Oscillibacter spp., with potential benefits for lipid homeostasis and cardiovascular health. 越来越多的证据表明心血管疾病(CVD)与肠道微生物组的改变有关。由于缺乏与诊断生物标志物...
RNA-seq was used to analyze genome-wide transcriptome changes ofTaxodium‘Zhongshansa 406’ clone root and shoot treated with 1 h of soil-waterlogging stress. After de novo assembly, 108,692 unigenes were achieved, and 70,260 (64.64%) of them were annotated. There were 2090 differentially ex...