Renfurm LN, Bandsma RH, Verkade HJ, Hulzebos CV, van Dijk T, Boer T, et al. Cholesterol synthesis and de novo lipogenesis in premature infants deter- mined by mass isotopomer distribution analysis. Pediatr Res 2004;56(4): 602e7 [Epub 2004/08/06]....
Role of de novo syntheses of cholesterol and bile acids in liver, gallbladder emptying, and intestinal transit time in supersaturated bile formation in cholesterol gallstone diseaseMT impedance tensorMohr circletwo dimensional structurewest Sichuan east Tibet...
The fractional contribution of newly synthesized cholesterol to plasma unesterified cholesterol was 7.4 +/- 1.3% after a 12-h infusion. The calculated rate of endogenous cholesterol synthesis was 31 +/- 7 mg/kg/d, a value approximately three times higher than that found in adult subjects (10...
Cytoplasmic cholesterol is transported into the mitochondria, where the rate-limiting enzyme CYP11A1 (also known as P450 side chain cleavage enzyme) converts cholesterol to pregnenolone. Pregnenolone is the first bioactive steroid of the pathway, and the precursor of all other steroids (Fig. 1a)1...
Cholesterol (Cho) is an essential lipophilic molecule in cells; however, both its decrease and its increase may favor the development of neurological diseases such as Alzheimer's disease (AD). Although copper (Cu) is an essential trace metal for cells, the increased plasma concentration of its ...
We also assessed the effect of simvastatin, an inhibitor of the mevalonate/cholesterol synthesis pathway on cancer cells in lipid- reduced and normal growth conditions. Low-lipid conditions also increased the sensitivity of cancer cells to this compound. There was a signifi...
The ability of naturally occurring proteins to change conformation in response to environmental changes is critical to biological function. While there have been advances in the de novo design of extremely stable proteins, the design of conformational switches remains a major challenge. ...
Kris-Etherton PM, Pearson TA, Wan Y, Hargrove RL, Moriarty K, Fishell V, Etherton TD: High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am J Clin Nutr. 1999, 70: 1009-1015. CAS PubMed Google Scholar Kerckhoffs DA, Brouns F, Hornstra ...
Fibrates (anti-hyperlipidemic agents) enhance the mRNA expression of uncoupling protein 2 (UCP2) in the liver and that of uncoupling protein 3 (UCP3) in skeletal muscle in standard-diet-fed rats and induce a de novo expression of UCP3 (mRNA and protein) in the liver of high-fat-fed rat...
20β-HSD, 17α-hydroxylase, aromatase P450, StaR) leading to sex steroids synthesis in the follicular layer. On the other hand, the receptors ldlr and srb1, thought to be involved into the internalization of LDL and HDL and thus representing the starting point for cholesterol uptake and ...