After corresponding interventions, the rat weight was measured, and serum creatinine, serum phosphorus, serum calcium and urea nitrogen levels were detected among four groups. Immunohistochemical staining and HE staining of the thoracic aorta tissues were used to evaluate the degree ...
Introduction: Osteoporosis results from the interplay of multiple environmental and genetic determinants. The gene encoding vitamin D-binding protein (DBP), a key factor for regulating calcium homeostasis through the vitamin D endocrine system, is a probable candidate for conferring susceptibility to osteo...
In addition, carbohydrate-responsive element-binding protein (ChREBP) has been shown to bind both directly and glucose dependently to the ARNT promoter in β-cells and to thereby down-regulate its transcription [17]. Investigating other regulators of ARNT should provide new insights into the ...
waters (Staples et al.1997). PAEs have been classified as top priority toxicants by the European Union, China National Environmental Monitoring Center and US Environment Protection Agency (Chen et al.2007; Council of the European Union1993). PAEs are responsible for carcinogenicity and endocrine di...
The effect allele was associated with an age- and sex-adjusted decrease in DBP level of 27.4 mg/l (95% CI 24.7, 30.0; n = 2,254). DBP had a strong observational and causal association with 25OHD levels (p = 3.2脳10?19). While DBP levels were observationally associated with calcium...
Vitamin D is one of the most important ones with its vital role in calcium homeostasis in our body. Vitamin D deficiencies would definitely bring about various skeletal and non-skeletal disorders. In this study we have assessed the influence of two single-nucleotide polymorphisms (SNPs) of GC ...
B Background b : DBP is a plasma protein with a molecular weight of 58 kDa that exists in the 2-globulin fraction. B Results b : There was no correlation between serum DBP and clinical laboratory data (serum IgE and calcium, peripheral eosinophil and neutrophil counts ...
Osteoclast activity was determined by evaluating pit formation using osteoclasts, isolated from the long bones of newborn rats, incubated on calcium phosphate coated, thin film, Ostologic MultiTest Slides. Incubation of osteoclasts with ex vivo generated native DBP- maf resulted in a dose dependent,...
Recent studies have reported that vitamin D (1, 25OH 2 D 3) has protective effects on the nervous system and it is suggested to exert its neuroprotective effects by modulating neuronal calcium homeostasis and production of neurotrophins. A recent genome wide association study (GWAS) which was ...
Vitamin D, essential for calcium homeostasis and bone mineralization, is transported and stabilized by vitamin D binding protein (VDBP). Common single nucleotide polymorphisms (SNPs) in the VDBP gene, rs4588 and rs7041, may influence serum vitamin D levels and potentially impact THR outcomes. ...