S100 proteinsSynaptotagminCa2+ binding proteins (CBP) are of key importance for calcium to play its role as a pivotal second messenger. CBP bind Ca2+ in specific domains, contributing to the regulation of its concentration at the cytosol and intracellular stores. They also participate in numerous ...
Calcium-Binding Proteins Calcium exerts its control in cellular function by virtue of its ability to regulate the activity of many different proteins, such as channels, transporters, and transcription factors. In the majority of cases, acalcium-binding proteinserves as an intermediate between Ca2+and...
Sign in to download full-size image FIGURE 39.3.Immunoreactivity for calcium binding proteins in the cortex. (A–C) Low-power photomicrographs from the dorsolateral prefrontal cortex of an unaffected control subject showing interneurons immunoreactive for calcium binding proteins: (A) parvalbumin, (B)...
modulatory activation of antioxidant pathways and specific inhibitory effects in some thiol-containing proteins. The thiol-oxidizing properties of organoselenium compounds are considered the molecular basis of their chronic toxicity; however, the acute use of organoselenium compounds as inhibitors of specific ...
14-3-3 proteins are mainly cytoplasmic molecules. It can form homodimers or heterodimers, and interact with various cellular proteins. They are phosphoserine-binding proteins that bind to the consensus motifs RSXpSXP and RXY/FXpSXP. These consensus motifs are present in almost all of the 14-3...
Antimicrobial proteins contribute to host-microbiota interactions and are associated with inflammatory bowel disease (IBD), but our understanding on antimicrobial protein diversity and functions remains incomplete. Ribonuclease 4 (Rnase4) is a potential antimicrobial protein with no known function in the in...
WNK-NKCC1 signaling can promote cancer cell migration [12,53,54,57]. One mechanism is that WNK1-OSR1 signaling induces interactions between NKCC1 and ezrin-radixin-moesin (ERM) proteins [12]. ERM proteins are responsible for the linkage of the actin cytoskeleton to membrane proteins, and th...
triphosphate receptor (IP3R3). After binding, IP3generates a calcium wave ([Ca2+]i), which involves the influx of Na+ions through activated transient receptor potential cation channel subfamily M member 5 (TRPM5) [49,55]. Some investigators believe that in addition to TRPM5-dependent ...
There are likely to be other sensors that process the Ca2+ signals or signature, as strongly suggested by the suppression of the CBL9 gene, encoding a calcium-binding protein, resulting in hypersensitivity to low K+ and ABA (Cheong et al., 2003; Pandey et al., 2004; Xu et al., 2006...
In specific, High Mobility Group Box Protein 1 (HMGB1) and S100 calcium-binding protein B (S100B) have been linked with Aβ plaques and the formation of advanced glycation end products (AGEs) in the brain of AD patients (Bortolotto and Grilli, 2016). The involvement of Aβ-TLR4-NLRP3-...