步骤1、我们可以在GWAS Catalog中按论文的PMID(33414549)进行搜索: 步骤2、下拉至Studies,点击非认知能力表型相应的编号:GCST90011874: 步骤3、找到Full Summary Statistics,这里代表的就是能够获得完整GWAS Summary Results的地方(again,凡事没有绝对,不一定每一个表型都提供): 步骤4、下载GWAS Summary Results至本地...
gwastagger
GWAS Catalog (European Bioinformatics Institute, 2023); https://www.ebi.ac.uk/gwas/ Yang, J. et al. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76–82 (2011). Article CAS PubMed PubMed Central Google Scholar Gupta, A. immunogenomics/sc-h2: v3.0...
write.table(f,"GWAS_AF_Finn.txt",sep = "\t",row.names = FALSE,quote = FALSE) #SMR/GSMR格式转化---GWAS catalog格式 library(tidyverse) library(data.table) setwd("稳健分析GCST274790_AF6414andFinn/GSMR/") g<-fread("AF-GCST006414-build37.f.tsv.gz") #读取GWAS数据 head(g) f<-sele...
Jian Yang and colleagues propose a method that integrates summary data from GWAS and eQTL studies to identify genes whose expression levels are associated with complex traits because of pleiotropy. They apply the method to five human complex traits and p
GWAS SNP data were downloaded from the website of UCSC genome browser (https://hgdownload.soe.ucsc.edu/goldenPath/hg19/database/gwasCatalog.txt.gz; on 21 December 2021) (15). A BED format file was created by extending the genomic coordinates of all SNPs by 5 kb up- and downstream. ...
The Database of Genotypes and Phenotypes (dbGaP), hosted by NLM, has been designated as the data repository for all GWAS supported by the U.S. government via its National Institutes of Health (NIH). This database, which contains both prospectively obtained and previously existing data, is one...
(Knights et al.,2011) were designed to unravel the origins of microbial communities. If researchers would like to focus on the regulatory relationship between genetic information from the host and microorganisms (Wang et al.,2018a), genome-wide association analysis (GWAS) might be a good choice...
Even if it is hard to control for genotypic, phenotypic, and environmental variance, however, at least one has some idea of what these concepts mean in GWAS research.With the HMP it is different. Distinctions between genotype and phenotype or between genomic and environmental factors are ...
Data Curation是科学数据的数字化,数据共享,集成管理,在图书馆创新服务中具有重要作用.文章简述了国内外几个开放存取平台,并以天津科技大学图书馆为例,分析高校图书馆创新服务的新举措.结果表明:利用Data Curation及数据库平台,实行分级,层次化,模块化管理很有效果,Find+及Elsevier平台运作使开放存取数据库资源实现整合检...