β-胡萝卜苷(β-daucosterol)和人参环氧炔醇(panaxydol)等活性成分,作用于EGFR、STAT3、MAPK14、白介素-2(IL-2)等靶点,调节癌症信号通路(Pathways in cancer)、细胞因子受体相互作用(Cytokine-cytokine receptor interaction)、突触细胞黏附分子(CAMs)等信号通...
Cytokine-cytokine receptor interaction Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and re...
This chapter describes the interaction of interleukin-6 (IL-6) with a soluble form of its cell surface receptor (sIL-6R), presents a procedure utilizing a competition approach that allows the determination of the equilibrium constant in solution thus avoiding any potential problems associated with ...
基于KEGG通路富集分析的薏苡仁不同成分对Cytokine-cytokine receptor interaction靶基因作用,目的:探讨薏苡仁不同组分对脾虚湿阻证大鼠细胞因子-细胞因子受体相互作用的影响及关键靶点。方法:以薏苡仁不同组分作用于脾虚湿阻证大鼠,通过其肠全基因表达谱测定,对筛选的差异基
Production of small-molecule antagonists,that block the cytokine–receptor interaction, may bemorefeasible,asstablebindingtoonlyoneoftheproteinshas to be achieved. Still, competing any protein–proteininteraction with a small molecule is a diff i cult task [14].Indeed, no approved small-molecule drug...
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Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells.
This chapter describes the interaction of interleukin-6 (IL-6) with a soluble form of its cell surface receptor (sIL-6R), presents a procedure utilizing a competition approach that allows the determination of the equilibrium constant in solution thus avoiding any potential problems associated with ...
and paracrine functions. These complicated cytokinebehaviorscannot be explained by the simple interaction between a cytokine and its receptor.1However, lectin-like characteristics of cytokines (summarized inTable 1) may provide an insight into their multiple functions, although their physiological significanc...
细胞因子-细胞因子受体相互作用(cytokine-cytokine receptor interaction)等信号通路等.分子对接结果证实连花清咳片中主要活性成分与核心靶点具有较为稳定的结合活性... 靳培培,尹玉洁,魏聪,... - 《中国药理学通报》 被引量: 0发表: 2023年 Cluster analysis of splenocyte microRNAs in the pig reveals key...