Fig. 6.GFI1 at the nuclear endpoints of T cell and ILC specific signaling pathways (A) Schematic depiction of the induction of GFI1 by Th2 specific cytokine receptor signalingviaSTAT5/6 and the T cell receptor. GFI1 induction leads to the upregulation of IL5, the repression of IL17 and...
Effective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is a functionally s
4, are expressed as the proportion of cells that are dead relative to the total number of cancer cells in the culture, minus the natural cell death observed in each condition. As shown in Fig. 4A, CIK cells generated by the cytokine-enriched media killed ~6% of the RB-Y79 cells after...
Error bars represent plus or minus SD. Normal intracellular IFN-γ by IL-2–activated mutant NK cells To investigate the role of p110γ and p110δ in cytokine production, we visualized intracellular IFN-γ by flow cytometry. When p110γ- or p110δ-deficient NK cells were stimulated by ...
& Drexler, H.G. ( 1994 ) Hodgkin's disease: a cytokine-producing tumor: a review . Critical Reviews in Oncogenesis , 5 , 473 – 538 .Gruss HJ, Hermann F, Drexler HG. Hodgkin's disease: a cytokine- producing tumor--a review. Crit Rev Oncogenesis 1994; 5: 473-538....
Defective cytokine expression but adult-type T-cell receptor, CD8, and p56lck mod- ulation in CD3- or CD2-activated T cells from neonates. Pediatr Res 1995; 37:64-9.Pirenne-Ansart, H., Paillard, F., De Groote, D., Eljaafari, A., Le Gac, S., Bolt, P., Franchimont, P., ...
Interleukin receptor antagonist IL-1β: Interleukin-1β IL-6: Interleukin-6 IP: Intraperitoneal Mzc: Minozac PoDG: Polymorph Dentate Gyrus TBI: Traumatic brain injury TNFα: Tumor necrosis factor α.References Jennett B: Epidemiology of head injury. J Neurol Neurosurg Psych. 1996, 60...
For cytokine receptor staining, control refers to fluorescence minus one control. Data were analyzed with FlowJo 10 Software. Quantification and statistical analysis Based on previous and preliminary studies in our lab, we predicted that the reported samples sizes would be sufficient to ensure adequate...
The functional characterization of ILEI to be a novel cytokine involved in epithelial/mesenchymal transition and the identification of biologically active ILEI provides the basis fo
Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed.