Cytochrome c biogenesis is the covalent ligation of heme b to an apocyt c. • Ccm is an intricate post-translational protein modification process. • Ccm-System I involves nine membrane-bound proteins working together. • The Ccm proteins are proposed to form a large multi subunit supercomp...
Cytochrome c biogenesis is an intricate process present in virtually all organisms, and ensures the covalent ligation of heme to an apocyt c (Fig. 1). It relies on major cellular functions such as protein translocation followed by post-translational modification, extra-cytoplasmic protein folding an...
CcdA is a predicted 26-kDa integral membrane protein with no clear similarity to any known cytochrome c biogenesis protein but seems to be related to a... T Schiött,C Von Wachenfeldt,L Hederstedt - 《Journal of Bacteriology》 被引量: 193发表: 1997年 Composition and function of cytochrome...
In addition, the role of a novel CcdA-like protein in cbb3 oxidase assembly is discussed. 展开 关键词: Cytochrome c Maturation and the Physiological Role of c-Type Cytochromes in Vibrio cholerae, Artículo DOI: 10.1128/JB.187.17.5996-6004.2005 ...
Molecular mechanisms of cytochrome c biogenesis: three distinct systems. Mol. Microbiol. 29, 383–396 (1998). Article CAS PubMed Google Scholar Babul, J. & Stellwagen, E. Participation of the protein ligands in the folding of cytochrome c. Biochemistry 11, 1195–1200 (1972). Article CAS ...
The biosynthetic process involves the periplasmic reduction of cysteine residues in the heme c attachment motif of the apocytochrome, transmembrane transport of heme b and stereospecific covalent heme attachment via thioether bonds. The biogenesis System II (or Ccs system) is employed by 尾-, 未- ...
The expression amount of the cyt c protein per 1 g of E. coli cell was 1.5 ± 0.2, 1.8 ± 0.2, 0.7 ± 0.1, 1.8 respectively. ± 0.3, and 2.0 ± 0.2 mg/g for WT, I76V, A5F/M11V, Y32F/Y41E, and quintuple mutant HT cyt ...
In addition to the apparent influence of fnr on the expression of c-type cytochromes (Table 1 and Figure 3), the Fnr protein(s) also appear to activate genes required for cytochrome c biogenesis. The H. seropedicae genome encodes system II-like machinery for cytochrome c maturation (...
Deshmukh M, Turkarslan S, Astor D, Valkova-Valchanova M, Daldal F (2003) The dithiol:disulfide oxidoreductases DsbA and DsbB of Rhodobacter capsulatus are not directly involved in cytochrome c biogenesis, but their inactivation restores the cytochrome c biogenesis defect of CcdA-null mutants. ...
摘要: Presents information on study which looked at Bacillus subtilis CcdA defective mutants pretaining to the late step of cytochrome c biogenesis. Information on cytochromes c synthesis; Methodology used in the study; Discussion on the labeling of B subtilis c type cytochromes with C-heme....