These proteins compose a heme delivery pathway, include an ABC transporter, a redox protein and a putative heme lyase.P. Giegé and J.M. Grienenberger and G. BonnardMitochondrionP. Giege, J.M. Grienenberger, G. Bonnard, Cytochrome c biogenesis in mitochondria, Mitochondrion 8 (2008) 61-...
and substrate specificity of HCCS; the role of HCCS in human disease; import of HCCS into mitochondria; import of apocytochromes c and c 1 into mitochondria and the close relationships with HCCS-dependent heme attachment; and the role of the fungal cytochrome c biogenesis accessory protein Cyc2...
cholerae ccmE gene, which is required for cytochrome c biogenesis. The resulting strain is deficient of all c-type cytochromes and allows us to characterize the physiological role of these proteins. Under aerobic conditions in rich medium, V. cholerae produces at least six c-type cytochromes, ...
3.3. The effect on cytochrome c biogenesis of replacement of other putative active-site residues of CcmH A recent crystal structure of CcmH from P. aeruginosa indicated the amino acids that form the active site of the protein [6] and therefore those that might be important in N-CcmH in ...
Cytochrome c biogenesis is the covalent ligation of heme b to an apocyt c. • Ccm is an intricate post-translational protein modification process. • Ccm-System I involves nine membrane-bound proteins working together. • The Ccm proteins are proposed to form a large multi subunit supercomp...
mitochondrial biogenesis signaling pathway (peroxisome proliferator-activated receptor gamma [PPARgamma] coactivator-1alpha [PGC-1alpha], mitochondrial transcription factor A mitochondrial [TFAM], mitochondrial transcription factor 2B [TFB2]), as well as the protein content of PGC-1alpha were determined...
c-type cytochromes are characterized by covalent attachment of haem to the protein by two thioether bonds formed between the haem vinyl groups and the cysteine sulphurs in a CXXCH peptide motif. In Escherichia coli and many other Gram-negative bacteria, this post-translational haem attachment is ...
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Physical Interaction of CcmC with Heme and the Heme Chaperone CcmE during Cytochrome c Maturation Biogenesis of c-type cytochromes requires the covalent attachment of heme to the apoprotein. In Escherichia coli, this process involves eight membrane prot... Q Ren,L Thony-Meyer - 《Journal of Biolo...
Consistent with this notion, western blot analyses showed that H292-V cells had higher MT-CO2 protein expression than parental H292 cells (Fig. 1e). Fig. 1: MT-CO2 is essential for tumor cell survival and tumor growth upon glucose deprivation. a–c H292 or glucose-starvation-resistant H292...