Upon induction of apoptosis, AIF translocates from the mitochondrial intermembrane space into the cytosol and subsequently gains access to the nucleus (Green and Kroemer, 2004). There, AIF induces peripheral chromatin condensation with high-molecular-weight DNA fragmentation in a caspase-independent ...
d Immunoblot analysis of TOM20, AIF, MICU1, NNT, NDUFS1, ACO2, CS, and CHAC1 in mitochondrial isolates subject to proteinase K treatment in the presence or absence of detergent; IMM inner mitochondrial membrane, IMS intermembrane space, OMM outer mitochondrial membrane. e ACO2 (n = ...
531 Cysteine proteinase 1, mitochondrial LAP3 52 6 532 ATP-dependent RNA helicase DHH1 DHH1 58 6 533 T-complex protein 1?subunit delta CCT4 58 8 534 D-lactate dehydrogenase [cytochrome] 3 DLD3 55 11 535 40S ribosomal protein S7-B RPS7B 22 4 536 Protein EMP47 EMP47 50 6 537 Prote...
Cysteine-rich intestinal protein 1 (CRIP1) is highly expressed in human intestine and aberrantly expressed in several types of tumor. However, studies on CRIP1 are limited and its role on tumor development and progression remains controversial and elusiv
Pro-inflammatory neutrophil serine proteases (NSPs), including neutrophil elastase (NE), proteinase 3, cathepsin G (CatG), and the recently discovered NSP4, are initially synthesized as inactive zymogens [9, 10] that are converted into their mature active form by cathepsin C (CatC, also known...
A. Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas. Nature 273, 545–547 (1978) Article ADS CAS PubMed Google Scholar Larminie, C. G. & Johnstone, I. L. Isolation and characterization of four developmentally regulated ...
Determinants of Mouse Hepatitis Virus 3C-like Proteinase Activity The coronavirus, mouse hepatitis virus strain A59 (MHV), expresses a chymotrypsin-like cysteine proteinase (3CLpro) within the gene 1 polyprotein. The MHV ... Y Lu,MR Denison - 《Virology》 被引量: 89发表: 1997年 COMPUTED QU...
Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus J. Biol. Chem., 267 (1992), pp. 17339-17346 View PDFView articleView in ScopusGoogle Scholar Lustigman et al., 1996 S. Lustigman, J.H. McKerrow, K. Shah, J. Lui, T. Hui...
Both de novo synthesis and degradation of proline involve metabolite intermediate D1-pyrroline-5-carboxylic acid (P5C) and are coupled to cellular energy and redox status, demonstrating the additional functions of this amino acid. During proline degradation, PRODH bound to the mitochondrial inner ...
Proteinase K assays Assays were performed as described previously21except that the chaperonin nucleotide reaction incubation time was extended to 60 minutes at 37 C. Briefly, ATPase buffer containing 0.25 µM MmCpn was pipetted onto the appropriate ATP conditions (no ATP, 1 mM ATP, ...