The present invention relates to a case of a new class of compounds cysteine protease inhibitors, including but not limited to Cathepsin K, L, S and B inhibitors. 这些化合物可用于治疗其中骨吸收需要加以抑制的疾病,如骨质疏松症. These compounds are useful in the treatment of which needs to be...
The cysteine protease CPR-4, a cathepsin B homologue, is identified as a radiation-induced bystander effect (RIBE) factor in nematodes in response to ultraviolet or ionizing radiation, and causes inhibition of cell death and increased embryonic lethality
Odanacatib(Cysteine Protease抑制剂)是有效,选择性的组织蛋白酶K抑制剂,IC50分别为0.2 nM和1 nM。对脱靶的cathepsin B,L,S具有高度选择性。在体外,Odanacatib作用于组织蛋白酶K具有高抑制活性和选择性,作用于人和兔组织蛋白酶K时,IC50分别为0.2 nM和1 nM。而且,在全部人细胞酶实验中,Odanacatib也同样有效,IC50为...
腐烂茎线虫(Ditylenchus destructor)是一种迁徙性植物寄生线虫,严重危害许多重要的农作物。这种害虫很难控制,因此迫切需要在农业生产中采取有效的管理策略。 Cathepsin L-like cysteine protease(CPL)是一种重要的蛋白酶,已被证明参与各种生理和病理过程。在此,该研究决定对腐烂茎线虫的 CPL 基因(Dd-cpl-1)进行鉴定。
ODANACATIB (CYSTEINE PROTEASE抑制剂)性质、用途与生产工艺 背景 Odanacatib(Cysteine Protease抑制剂)是有效,选择性的组织蛋白酶K抑制剂,IC50分别为0.2 nM和1 nM。对脱靶的cathepsin B,L,S具有高度选择性。 在体外,Odanacatib作用于组织蛋白酶K具有高抑制活性和选择性,作用于人和兔组织蛋白酶K时,IC50分别为0.2 nM...
classes of cysteine proteases, more progress has been made in the optimization of selective cathepsin inhibitors and activity-based probes, and as such, understanding the trials and tribulations associated with cathepsin inhibition will likely inform the production of inhibitors for other protease classes...
2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) 是半胱氨酸蛋白酶组织蛋白酶 K (cysteine protease cathepsin K) 的非选择性抑制剂(IC50:170 nM)。它能够用于骨质疏松症的研究。 ¥ 99 现货 规格 数量 Acetyl-Calpastatin (184-210)(human) acetate TP2056L Acetyl-Calpastatin (184-210)(human) aceta...
cathepsin K correlate with the extent of radiographic damage. A potential role of cathepsins as mediators of bone destruction in arthritis was confirmed in studies in which cysteine protease inhibitors significantly decrease joint damage in the rodent arthritis models. In the TNF-transgenic mouse model...
Cathepsin cysteine protease inhibitors 发明人: Stachel Shawn;Paone Daniel V.;Li Jing;Ginnetti Anthony;Lim John;Fu Jianmin;Xu Shimin 申请人: 申请日期: 2014-10-03 申请公布日期: 2017-02-21 代理机构: 代理人: Merck Sharp & Dohme Corp. 地址: Rahways NJ US 摘要: This invention relates to...
Protease/Metabolic Enzyme--Cathepsin CAS号(CAS NO.) 88321-09-9 分子式(Formula) C17H30N2O5 分子量(Molecular Weight) 342.43 外观(Appearance) 粉末 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 结构式(Structure) 运输和保存方法 -25~-15℃保存,有效期3年。