In this study, we analysed the cysteine protease ATG4B of Trichinella spiralis (TsATG4B) isolated from the soluble proteins of Trichinella spiralis (T. spiralis) adult worms to ascertain its biochemical properties and functions during invasion into the intestine of the host. The 43 kDa recombinant ...
LV-320 是一种有效且非竞争性的ATG4B 抑制剂,其IC50值为 24.5 μM,Kd 值为 16 μM。 LV-320 抑制ATG4B 的酶促活性,阻断细胞自噬,并且稳定无毒,在体内具有活性。 规格价格库存数量 25 mg¥ 11,7596-8周 50 mg¥ 18,7006-8周 100 mg¥ 26,4376-8周 ...
2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) 是半胱氨酸蛋白酶组织蛋白酶 K (cysteine protease cathepsin K) 的非选择性抑制剂(IC50:170 nM)。它能够用于骨质疏松症的研究。 ¥ 99 现货 规格 数量 Acetyl-Calpastatin (184-210)(human) acetate TP2056L Acetyl-Calpastatin (184-210)(human) aceta...
世联博研公司现货供应MYBIOSOURCE INC.品牌订货号为MBS7206733的Canine Cysteine protease ATG4B (ATG4B) ELISA Kit from MYBIOSOURCE INC.产品
The cysteine protease ATG4B is a key component of the autophagy machinery, acting to proteolytically prime and recycle its substrate MAP1LC3B. The roles of ATG4B in cancer and other diseases appear to be context dependent but are still not well understood. To help further explore ATG4B functions ...
namely cathepsin B (CATB, KT194088), cathepsin L (CATL, KT194089), caspase–1 (CASP1, KT194090), caspase–8 (CASP8, KT194091), autophagy protease 4B (ATG4B, KT194092) and autophagy protease 4D (ATG4D, KT194093), were cloned successfully from the cDNA library of the salivary glands ...
Furthermore, we demonstrated that autophagy-related 4B cysteine peptidase (ATG4B) may be a potential target of NC, since overexpression of ATG4B reversed the cardiac hypertrophy and reduced autophagy levels observed in NC-treated mice. We conclude that NC induces cardiac hypertrophy via ATG4B-mediated...
Legumain is a newly discovered lysosomal cysteine protease that can cleave asparagine bonds and plays crucial roles in regulating immunity and cancer metastasis. Legumain has been shown to be highly expressed in various solid tumors, within the tumor microenvironment and its levels are directly related...
However, HsLC3A is processed when coexpressed with HsATG4B in plants. Molecular modeling indicates that lack of processing of HsLC3A by plant and yeast ATG4 is not due to lack of interaction with HsLC3A. Our in-depth analyses of ATG4 and ATG8 in the plant lineage combined with results...
FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays. 靶点活性 Autophagin-1 (FRET assay):80 nM, Autophagin-1 (LRA assay):73 nM 体外活性 FMK 9a与位于ATG4B催化位点的Cys74中更活跃的硫醇基团形成共价键,从而使ATG4B的蛋...