The coincidence ratio with a sequencing method of the CYP2D6 gene mutation detection liquid-phase chip reaches up to 100 percent, and the CYP2D6 gene mutation detection liquid-phase chip has higher specificity and precision compared with intra-class correlation products....
Gene CYP2D6 Mutation Type 1 AA Change: N/A DNA Change: NM_000106.6:c.985+39G>A Chr position (GRCh38):chr22:42127803 Mutation Type 2 AA Change: p.R296C DNA Change: NM_000106.6:c.886C>T Chr position (GRCh38):chr22:42127941 Mutation Type 3 AA Change: N/A DNA Change...
et al. CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res 12, R64 (2010). https://doi.org/10.1186/bcr2629 Download citation Received04 March 2010 Revised08 July...
% Results The% frequencies% of% CYP2D6%(CYP2D6/C188, % CYP2D6/L2938, % CYP2D6/G4268) % gene% mutations% were%higher% in% HSLE% patients% than% in% the% controls.% Conclusion The% CYP2D6% gene% mutation% is% associated% with% a% high% risk% of% HSLE.%Key words: heroin;%...
GQ Zhang - 《Mutation Research/genetic Toxicology & Environmental Mutagenesis》 被引量: 149发表: 1999年 CYP2D6 gene polymorphism in Caucasian smokers Benhamou S,et al.CYP2D6 gene polymorphism in caucasian smokers:lung cancer susceptibility and phenotype-genotype relationships[J].Eur J Cancer,2000,36...
The present invention belongs to the field of biology, involving CYP2D6 allele Article 2943 of the single base mutation, the site of G to A. 具体地,本发明涉及包含该突变位点的核酸片段及其相应编码的蛋白质片段,鉴定所述突变位点的试剂,检测方法和该位点的应用,特别是鉴定该位点在指导用药中的应用. ...
Am J Hum Gene 1997; 60: 284–295. CAS Google Scholar Raimundo S, Toscano C, Klein K, Fischer J, Griese E-U, Eichelbaum M et al. A novel intronic mutation, 2988G>A, with high predictivity for impaired dunction of cytochrome P450 2D6 in white subjects. Clin Pharmacol Ther 2004...
ABSTRACT OBJECTIVE:To set up a genotyping method for CYP2D6E allele which is a 3023 A→C mutation on CYP2D6 gene and result in a function deficient enzyme.METHOD:Two pairs of primers were designed to separately amplify wildtype and mutant CYP2D6E allele based on the principle of allele-spe...
Among Chinese, not only is the frequency of the poor metabolizer phenotype low, the contribution of the 29B mutation in the CYP2D6 gene is insignificant. By contrast the frequency of D6-J is very common (approximately 0.6) and is clearly related to the activity of debrisoquine hydroxylase. ...
andreferredtoclinicaldrugtherapy.MethodsPolymerasechainreactionsfPCRlweRusedtoampllfyCYP2D6geneof2129volunteersAlterexaminedbyagarosegelelectrophoresls,directsequenceswereultiiizedtoscanthenineexon￥ofCYP2D6IfanowImutationhasbeendetected,didirectinnwouldbeconductedInorderSOexludetheartificalergothatinducedbyPCRandmake...