Metabolic pathwayEnzymeInductionThis chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of P450 CYP2C9.doi:10.1007/978-1-4614-7495-1_10Byron Douglas FergersonCrystal B. WallentineRandal O. DullSpringer New York...
Substrates, Inducers, Inhibitors and Structure-Activity Relationships of Human Cytochrome P450 2C9 and Implications in Drug Development. Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolb...
Also of concern are oral hypoglycemicdrugs. As with warfarin, the effect ofCYP2C9 inhibitors or inducers can becompensated for with dosage adjustmentsof the CYP2C9 substrate. If theCYP2C9 substrate dose has beenincreased to compensate for a CYP2C9inducer, however, stopping the inducercan res...
What most people fail to realize is that herbal preparations contain constituents, which may serve as CYP substrates, inhibitors or inducers, hence affecting the biotransformation of co-administrated medications. Many studies have reported the interaction between herbs and conventional medicines (Nicole ...
Zhou, SF, Zhou, ZW, Yang, LP (2009) Substrates, inducers, inhibitors and structure-activity relationships of human cytochrome p450 2c9 and implications in drug development. Curr Med Chem 16: pp. 3480-3675Zhou, S. F., Zhou, Z. W., Yang, L. P. and Cai, J. P. 2009 . Substrates...
In addition togenetic polymorphisms, non-genetic factors (co-medication with CYP2C9-specific inhibitors/inducers and non-specific factors including amoxicillin+clavulanic acid therapy or chronic alcohol consumption) contributed to the prediction of hepatic CYP2C9 activity; however, a CYP2C9 genotype–...
Summary Aims Avatrombopag, a thrombopoietin receptor agonist, is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A. We assessed three drug-drug interactions of avatrombopag as a victim with dual or selective CYP2C9/3A inhibitors and inducers. Methods This was a 3-part, open-label ...
The aim of our study was to evaluate the phenoconversion of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 drug-metabolising enzymes in a series of autopsy cases tested positive for drugs that are substrates, inducers, or inhibitors of these enzymes. Our results showed a high...
Patients who did not provide informed written consent, did not visit the anticoagulation clinic regularly, took CYP2C9 inducers or inhibitors, or did not have a complete data set were excluded. Initially, 350 patients were screened and, based on the aforementioned inclusion and exclusion criteria...
Patients who did not provide informed written consent, did not visit the anticoagulation clinic regularly, took CYP2C9 inducers or inhibitors, or did not have a complete data set were excluded. Initially, 350 patients were screened and, based on the aforementioned inclusion and exclusion criteria,...