The use of pyrazolo-triazine derivatives of formula (I), in the form of racemates, enantiomers or their combinations, or their salts is claimed in the preparation of cyclin dependent kinase (CDK) inhibiting medicaments. A = H, halo, CHO, CN, NO2, guanidinoaminomethylenyl, (1,3-dihydro-2...
(A) In BHP7-13 cells, dinaciclib (25 nM) decreased CDK1 and cyclin B1 l... SF Lin,JD Lin,C Hsueh,... 被引量: 0发表: 2017年 Receptors for parathyroid hormone and parathyroid hormone–related protein Effects of dinaciclib on the expression of proteins associated with the cell cycle. (...
Mechanism Governing Maintenance of Cdk1/Cyclin B1 Kinase Activity in Cells Infected with Human Cytomegalovirus. Previous work has demonstrated dysregulation of key cell cycle components in human cytomegalovirus (HCMV)-infected human fibroblasts, resulting in cell cyc... Sanchez,Veronica,McElroy,... -...
“The initiation of dosing in this study marks a major milestone for NiKang, as NKT3447 is the first of our pipeline programs targeting the cell cycle to begin clinical evaluation,” said Zhenhai Gao, Ph.D., co-founder, president, and CEO of NiKang. “We have strong conviction that CDK2...
Les inhibiteurs des CDK-cyclines dans les mélanocytes choroïdiens normaux ettransformésdoi:10.1016/S0370-4475(80)80011-6Analysis of polygraphic recordings of nocturnal sleep in 21 patients with 芦 degenerativedementia led to the identification of two types of tracing. The first type was ...
A method of assaying the phosphorylation activity of a cyclin/CDK complex on RB protein which comprises evaluating the phosphorylation of RB protein phosphorylated by the cyclin/CDK complex by an immunological method with the use of an antibody capable of distinguishing the phosphorylated state; and ...
inhibiteurs des CDK (CKI)senescence replicativeReplicative senescence is defined for human diploid fibroblasts in culture as a cell growth arrest appearing beyond 50 +/- 10 population doublings and associated with telomeres' shortening. This phenomenon shows an increased expression of growth cell ...
(2004) Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16 (INK4a). Oncogene 23, 491-502.Faast, R., White, J., Cartwright, P., Crocker, L., Sarcevic, B., and Dalton, S. (2004). Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition...
Two Distinct Controls of Mitotic Cdk1 / Cyclin B1 Activity Requisite ND ES SC Key wordS RIBMiyazaki, Toru
Cyclin D1 in cooperation with its major catalytic partners, cyclin-dependent kinases cdk4 and cdk6, facilitates progression through the G1 phase of the eukaryotic cell cycle, in part through phosphorylation of the retinoblastoma protein. Cyclin D1's oncogenic properties have been suggested by its ...