Cyclin B1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It interacts with the Cdc2 protein kinase to form MPF (mitosis promoting activator). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Increased expression is often ...
2024年9月4日,哈佛大学医学院附属丹娜法伯癌症研究院放射肿瘤研究部主任Dipanjan Chowdhury和Alexander Spektor教授带领的研究团队在Nature上发表了题为“CDK5-cyclin B1 regulates mitotic fidelity”的研究论文,深入阐述了非经典细胞周期调控因子CDK5在细胞有丝分...
细胞周期蛋白cyclin:哺乳动物中有cyclinA～H八类,cyclinD有D1、D2、D3,cyclinB有B1、B2。具有调节CDK的功能,CDK和cyclin结合形成异二聚体起作用。cyclin在细胞周期过程中会出现周期性的降解,对细胞周期调控起关键作用。 CDK (cyclin dependent kinase):即周期蛋白依赖性激酶,各种CDK沿细胞周期时相交替活化,磷酸化...
Hamster Cyclin B1 偶联物 Unconjugated 形式 Liquid 浓度 1 mg/mL 纯化类型 Protein A 保存液 PBS with 30% glycerol, 1mg/mL BSA 内含物 0.05% sodium azide 保存条件 -20°C 运输条件 Ambient (domestic); Wet ice (international) RRID AB_2536863 ...
Cyclin B1 Rabbit Monoclonal Antibody -20℃保存,Western一抗稀释液-20℃或4℃保存,一年有效。Western一抗稀释液优先推荐4℃保存,长期不使用可以考虑-20℃保存,但冻融可能会导致出现轻微的浑浊和少量不溶物。 注意事项: 如果本抗体用于Western blot (WB)、免疫荧光(IF)、免疫细胞化学(ICC)等实验,请注意回收使用...
Mitotic kinase purified from AD and normal brain, using the yeast p13suc1 protein as affinity ligand, showed higher histone H1 phosphorylation activity in AD. Accordingly, the levels of cdc2 and cyclin B1 in p13suc1 fractions from AD were higher than normal. Consistent with a physiological ...
By contrast, cyclin B1 transcription is repressed during G2 arrest induced by DNA damage. The p38 mitogen-activated protein kinase is involved in the G2 checkpoint; yet, its impact on cyclin B1 protein levels remains unclear. Here we show that untimely proteolysis of cyclin B1 following p38 ...
Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly duri...
Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly duri...
a) G1/S arrest:2mM胸腺嘧啶处理24h的HeLa细胞,细胞周期蛋白D1(Cyclin D1)、Cyclin B1、Cyclin B2和叉头框蛋白M1(FOXM1)上调。 图9 Cyclin D1抗体(26939-1-AP,A)和FOXM1抗体(13147-1-AP,B)检测处理前后Hela b) G2/M arrest:100ng/mL诺考达唑处理18h的HeLa细胞,Cyclin B1、Cyclin B2、FOXM1、细胞分...