Following an initial bioinformatics screen, the present study focused on cyclin B1 (CCNB1) in LUAD. A total of 94 patients with LUAD from a single hospital were included in the study. CCNB1 protein expression was detected and scored in 94 LUAD samples and 30 normal tissue...
Cyclin B1在早期乳腺癌的作用尚需进一步研究。 【关键词】Cyclin B1早期乳腺癌预后 Expression and significance of Cyclin B1 in early breast cancer Ou Hai-ling1 Liu Jian-lun2 Qin Yu-zhou2 【Abstract】Objective: To observe retrospectively the protein expression and significance of Cyclin B1 in early ...
Northern-blot analysis indicated that the radiation-induced decrease in cyclin B1 protein expression was accompanied by a reduced cyclin B mRNA level. On the whole, our results indicate a direct inhibitory effect of 10 Gy irradiation on cyclin B1 expression as a possible cause for the persiste...
et al. High cyclin B1 expression is associated with poor survival in breast cancer. Br. J. Cancer 100, 1055–1060 (2009). CAS PubMed PubMed Central Google Scholar Nimeus-Malmstrom, E. et al. Cyclin B1 is a prognostic proliferation marker with a high reproducibility in a population-...
The survival rate in cyclin B1 high expressed patients was higher than that in cyclin B1 low expression patients. A negative correlation between the expression of cyclin B1 and p21~ ciplwas observed. Additionally, cyclin B1 protein expression was generally correlated with proliferation index (PI) ...
Proliferation,CellCycleand Cyclin81ProteinExpressionOf ColonCarcinomaCelILine SW480 URun-qing.SHANBao-en rResearchCenteroftheFourthHospi~lofHebeiMedical University,Sh~iazhuang050011,Hebei,China) 【摘要】背景与目的:探讨槲皮素对人结肠癌细胞SW480增殖、凋亡、细胞周期及CyclinB1蛋白表达的影响,并探讨其抗肿瘤机...
doi:EP0858346 B1not available for EP0858346of corresponding document: WO9716209 A method of treating a tumor (in particular osteosarcoma or Ewing's sarcoma) in a host by administering to a host or to the tumor cells an agent which inhibits cyclin G1 protein in an amount effective to inhibit...
23.Gong J, Ardelt B, Traganos F, Darzynkiewicz Z. Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines.Cancer Res. 1994;54:4285-4288.[PubMed] 24.Resnitzky D, Gossen M, Bujard H, Reed SI. Accele-ration of the G1/S phase transition by...
At this time point, cyclin B1 protein level was barely detectable, and therefore CDK1 should not be active. In addition, ectopic expression of cyclin B1 did not inhibit pre-RC assembly (Supplementary Fig. 8). Thus, we concluded that the rescue effect of dinaciclib was not due to CDK1 ...
Cyclin AmRNA accumulates and diminishes at the similar time as its protein, slightly ahead ofcyclinB mRNA[13]. The promoters ofcyclin A2[16],cyclin B1[17], andcyclin B2[18,19]contains CCAAT-boxes that bind the trimeric NF-Ytranscriptional activator. The coactivator p300 binds to the promoter...