PR,HER2.Method:Atotalof76patientswithEBCwerefollowedupinthisstudy.TheproteinexpressionsofCyclinB1,ER,PRandHER2inthesepatientsweredetectedbyImmunohistochemicaltwo-stepmethodandstatisticallyanalyzed.Result:ThepositiveratesofproteinexpressionofCyclinB1
Following an initial bioinformatics screen, the present study focused on cyclin B1 (CCNB1) in LUAD. A total of 94patients with LUAD from a single hospital were included in the study. CCNB1 protein expression was detected and scored in 94 LUAD samples and 30 normal tissue ...
Western blot analysis, performed with a monoclonal anticyclin B1 antibody, revealed in compe- tent and incompetent oocytes a polypeptide of 65kDa corresponding to the goat cyclin B1 protein. This pattern of cyclin B1 expression further suggested that meiotic incompetence in goat oocytes could not be...
Thenthecelproliferation,cellcycle,apoptosisrateandcyclinB1proteinexpressionofSW480celswereanalyzed usingMTrassay,floweytometryand immunoblotmethods,respectively.RESULTS:ProliferationofSW480cellswas promotedbyquereeteinataconcentrationof20~mol/L(P<0.05),whileitwassignificantlyinhibitedbyquercetinat ...
However, the mechanism of cyclin B1 up-regulation and the effects of the up-regulation on the host cells remain unclear. Here, we show that HIV-encoded Tat protein regulates cyclin B1 levels in two different ways: first, Tat stimulates the transcription of cyclin B1, which increases cyclin ...
Cyclin B1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It interacts with the Cdc2 protein kinase to form MPF (mitosis promoting activator). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Increased expression is often ...
doi:EP0858346 B1not available for EP0858346of corresponding document: WO9716209 A method of treating a tumor (in particular osteosarcoma or Ewing's sarcoma) in a host by administering to a host or to the tumor cells an agent which inhibits cyclin G1 protein in an amount effective to inhibit...
Cyclin B1在肿瘤发生发展过程中起作用。 Cyclin B1过表达能促进G /M期转换,甚至导致细胞 一、 Cyclin B1与细胞周期调控 增生失控以及恶性转化 ;过表达转录因子c—Myb Cyclin B1是在有丝分裂过程中起调控作用的周 能够刺激Cyclin B1表达,进而促进G /M期转换 ; 期蛋白,它作为调节亚基参与MPF活化调节,进而参 Yuan ...
DADS对MSB-1细胞发生G2M期阻滞中CDK1、CyclinB1蛋白的影响.docx,DADS对MSB-1细胞发生G2/M期阻滞中CDK1、CyclinB1蛋白的影响 Effect of dads on CDK1 cyclinb1 protein during g 2 / M phase arrest in msb-1 cells 目录 摘要 1 关键词 1 TOC \o 1-3 \f \u 1 前言 5 2 材料
Target Protein Cyclin B1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC-p Recommended Dilution WB: 1:500-1:2000 IHC: 1:50-1:200 Concentration 1 mg/ml Reactive Species Human,Rat,Mouse Host Species Rabbit Immunogen Recombinant Protein of Cyclin B1 Specificity The antibody...