Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev 1999;13:1190e202.Kaiser P, Moncollin V, Clarke DJ, Watson MH, Bertolaet BL, Reed SI, and Bailly E (1999). Cyclin-dependent kinase and Cks/Suc1 interact with...
Fig. 4.Pathways of different common targets affecting type 2 diabetes mellitus and colon cancer. AC: Adenylatecyclase; cAMP: cyclic adenosine monophosphate; CDK: Cyclin dependent kinase; CREB: cAMP response element-binding protein; DPP-4: Dipeptidyl peptidase-IV; ER: Estrogen receptor; GLP: Glucago...
Cyclin-dependent kinase (CDKs) (CDKA:1, CDKB2:1, and CDKD1:1) from the root tip cells of Allium cepa by using RT-qPCR. These Cyclin-dependent kinases (CDKs) are known to be the major regulators of the eukaryotic cell cycle. In response to phytohormonal signals, they are thought ...
Cyclin-dependant kinase 4 (CDK4) and CDK6 phosphorylate the tumour suppressor retinoblastoma protein (RB), resulting in the release of the E2F transcription factor and progression through the cell cycle. CDK4 and CDK6 are positively regulated by D-type cyclins (that is, cyclin D1, cyclin D2...
CDK1, cyclin-dependent kinase 1; GST, glutathione-S-transferase. We next tested whether phosphorylation by the CDK1–cyclin B complex affects the A22- or ACN-type interaction. To monitor and distinguish the ACN mode and A22 interactions, we used two lamin N-terminal fragments and one lamin ...
The yeast cell cycle is largely controlled by the cyclin-dependent kinase (CDK) Cdc28. Recent evidence suggests that both CDK complex stability as well as function during mitosis is determined by precise regulation of Swe1, a CDK inhibitory kinase and cy
In this study, using exocytic secretion, cyclin-dependent kinase (CDK) assay, immunoprecipitation, and microscopy, we demonstrate that the exocyst subunit Exo84, which is known to be phosphorylated in mitosis, can also be phosphorylated directly by Cdk1 in the late G1 phase. Of note, we ...
Although we did not identify any highly Clb2-specific substrates, we found that Clb2 - Cdk1 possessed higher intrinsic kinase activity than Clb5 - Cdk1, enabling efficient phosphorylation of a broad range of mitotic Cdk1 targets. Thus, Clb5 and Clb2 use distinct mechanisms to enhance the ...
Here, we show that the protein phosphatase PP2A(Cdc55) dephosphorylates APC/C, thereby counteracting the activity of the mitotic kinase Cdc28. We also observe that the key regulator of Cdc28, the mitotic cyclin Clb2, increases before cells adapt and is then abruptly degraded at adaptation. ...
The present disclosure relates to, in an embodiment thereof, a cyclin-dependent kinase substrate (sometimes also referred to herein as “the substrate of the present disclosure”) including a polypeptide that contains an amino acid sequence represented by formula (1): R1—P (wherein R1represents ...