cyclin B1AnaphaseMammalsdegradationPersonal failure后期哺乳动物Recently, it has been shown that cyclin B1 was degraded mainly before the onset of anaphase in mammalian cells. When a nondegradable form of cyclin B1 was introduced into cells, the metaphase-anaphase transition was blocked. This blockage ...
Here, we show that HIV-encoded Tat protein regulates cyclin B1 levels in two different ways: first, Tat stimulates the transcription of cyclin B1, which increases cyclin B1 levels and promotes the cells apoptosis; and second, Tat stimulates polyubiquitination-mediated degradation of cyclin B1 ...
(2009). p21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage. Cell Cycle 8: 253-256.Gillis LD, Leidal AM, Hill R, Lee PW. p21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage. Cell Cycle. 2009;8:253-256....
6d–h). These findings indicate that CDK1–cyclin B1 generates a phospho-degron on KIND1 and KIND2, which recruit the CUL9–FBXL10 complex that in turn ubiquitinates and routes the protein to the proteasome for degradation. Furthermore, the observation that CUL9 and FBXL10 are present ...
2024年9月4日,哈佛大学医学院附属丹娜法伯癌症研究院放射肿瘤研究部主任Dipanjan Chowdhury和Alexander Spektor教授带领的研究团队在Nature上发表了题为“CDK5-cyclin B1 regulates mitotic fidelity”的研究论文,深入阐述了非经典细胞周期调控因子CDK5在细胞有丝分...
4b, both accumulation and degradation kinetics of Geminin protein was similar with or without cyclin K knockdown. Cyclin B1 protein was also degraded at a comparable rate. CDT1 activity is tightly controlled by proteasome6. Treatment with proteasome inhibitor increased the level of free CDT1 to a...
shape.Here,weshowthatimpairedcyclinB1degradation,resultingfromamutationwithinitsdestructionbox,leadsto anisodiametricshapeofepidermalcellsinleaves,stems,androotsandretardedgrowthofseedlings.Microtubulesin thesemisshapedcellsaregrosslydisorganized,focusedaroundthenucleus,whereastheywereentirelymissingor ...
Cyclin AmRNA accumulates and diminishes at the similar time as its protein, slightly ahead ofcyclinB mRNA[13]. The promoters ofcyclin A2[16],cyclin B1[17], andcyclin B2[18,19]contains CCAAT-boxes that bind the trimeric NF-Ytranscriptional activator. The coactivator p300 binds to the promoter...
Cyclin B1 interacts with the BH3-only protein Bim and mediates its phosphorylation by Cdk1 during mitosis. 来自 Semantic Scholar 喜欢 0 阅读量: 59 作者: Mac Fhearraigh, Seán, Mc Gee, Margaret M.摘要: Protracted mitotic arrest leads to cell death; however, the molecular signals that link...
Both effects are likely attributable to either cyclin B1 accumulation in the case of NIPA inactivation by siRNA or untimely cyclin B degradation at G2/M upon expression of the constitutively active SCFNIPA complex. Cyclin B1 is physiologically kept cytoplasmic during interphase and premature nuclear ...