CXCR6 在树突状细胞(dendritic cell,DC)促使 T 细胞分化期间表达增加,主要在 T 辅助细胞 1(Th1) 或细胞毒性 T 细胞 1 上表达。其他一些类型的 T 细胞也有表达。 大多数表达 CXCR6 的细胞缺乏至少 1 种淋巴器官归巢受体,这表明,CXCR6 表达是免 疫细胞分化的标志。部分研究认为,CXCR6也可在CD19+B细胞中表达。
趋化因子受体CXCR6主要表达于记忆T细胞和活化的Th1和Tc1效应T细胞亚群上,CXCR6对由CD8+ 细胞毒性T细胞(CTLs)介导的肿瘤控制至关重要。然而,CXCR6在TNBC中的临床价值尚不明确。在这项研究中,研究者发现CXCR6可以提示更好的预后和更佳的辅助放疗疗效。同时,CXCR6的富集参与了T细胞活化、激活TME,与免疫治疗的疗效...
CONCLUSIONS: CXCR6 was overexpressed in Th1 and Tc1 TLs compared with PBLs in GD. CXCR6 could be a marker for lymphocytes that have migrated into the thyroid and assist in the thyroid, independently of the bias of the underlying disease....
Sample: Human PBMCs Stimulated to Induce Th1 Cells Formulation, Preparation, and Storage Purification Protein A or G purified from ascites Formulation Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide. Shipping The product is shipped with polar packs. Upon receipt, st...
(Kawano et al., 1998). NKT cells also have the distinct ability to direct a response by producing Th1, Th2 and Th17 cytokines without being polarized. Secretion of IFN-γ by NKT cells directs NK cells to activate CD8+CTLs that are critical for anti-tumour responses and fighting ...
Activated CD4 + T helper cells (Th) comprise at least two functionally distinct subsets, Th1 and Th2, which mediate different immunological effector functi... P Kropf,Q Bickle,S Herath,... - 《European Journal of Immunology》 被引量: 0发表: 2002年 CXCR5+ST2+memory Th2 cell reduced matur...
The CXCL16-CXCR6 axis is crucial for regulating the persistence of CD8 tissue-resident memory T cells (TRM). CXCR6 deficiency lowers TRM cell numbers in th
Natural killer cells (NK) are highly enriched in the human liver, where they can regulate immunity and immunopathology. We probed them for a liver-resident subset, distinct from conventional bone-marrow-derived NK. CXCR6+ NK were strikingly enriched in h
CXCR3在将效应T细胞迁移到炎症和肿瘤部位中起着关键作用。CXCR3活化优先导致在Th1型CD4+T淋巴细胞、效应CD8+T淋巴细胞,NK细胞和NKT细胞的高表达。CXCR3及其配体分布在不同的身体组织中,其表达可以调节不同免疫细胞的定向迁移。它还可以显著减少内皮细胞DNA合成,促进血...
Th17/Treg失衡与肾移植免疫排斥反应的关系 目的很多年来,人们对Th1和Th2细胞有过大量的研究和探讨。然而,随着CD4+T细胞亚群认识的逐渐深入,这种传统的简单二分法已经遭到分歧。产生炎症促进因子IL-17的Th17细胞... 王振兴,陈花,武小桐,... - 中国器官移植大会 被引量: 0发表: 0年 加载更多来源...