通过在Cxcr3基因目的exon 2两侧分别插入loxP位点,构建Cxcr3-Flox小鼠。该flox小鼠可与组织特异性Cre工具鼠交配,获得在特定细胞类型或组织中敲除Cxcr3基因的小鼠模型。 *使用本品系发表的文献需注明: Cxcr3-Flox mice (Cat. NO. NM-CKO-2117369) were purchased from Shanghai Model Organisms Center, Inc.. ...
通过在Cxcr3基因目的exon 2两侧分别插入loxP位点,构建Cxcr3-Flox小鼠。该flox小鼠可与组织特异性Cre工具鼠交配,获得在特定细胞类型或组织中敲除Cxcr3基因的小鼠模型。 *使用本品系发表的文献需注明: Cxcr3-Flox mice (Cat. NO. NM-CKO-2117369) were purchased from Shanghai Model Organisms Center, Inc.. ...
外周CD45+流式染色实验进一步验证肺脏中这群细胞属于lungs-BRMs。随后,作者使用Tfh缺失的小鼠(Bcl6fl/flCd4cre/+)以及Tfh阻断方法(anti-CD40L),均证实lung-BRMs的分化需要Tfh辅助,且这种辅助发生在感染的早期3周内。 紧接着,作者检...
However, CD8αCre-ALK5flox/flox (ALK5ΔCD8) mice reject tumors in high proportions, dependent on CD8+ T cells. ALK5ΔCD8 mice have more tumor-infiltrating effector CD8+ T cells, with more cytotoxic capacity. ALK5-deficient CD8+ T cells exhibit increased CXCR3 expression and enhanced ...
Cresei ol il ml 研究MMI降低人类甲状腺细胞对CX CLl0的分泌。用MMI 治疗的甲功正常的随机病人 外,Antonellit23研究发现过氧化物酶增殖体受体激动 剂罗格列酮有抑制CXCLl 0分泌的作用。 循环CXCLl0的下降,可以归为已知的抗甲状腺药 虽然CXCLl0不仅在Graves病中出现,也可以 ...
in cre ase d l14】 . O ur rece nt stu d ie s do cum e nte d t ha t C X C R 3 is inv olv e d in acu te pu lmon ary in fl a m m a tion ind uce d by short — term ex posu re of C S throu g h re cru itm e nt of C D 8 + T cells in to lung ...
The development of pDC-restricted Cre-lox candidate gene deletion strategies is essential to test these candidates formally. In this study, we uncover essential functions for pDCs in innate antifungal defense that cannot be compensated by the presence of other myeloid cells, including neutrophils, ...
通过在Cxcr3基因目的exon 2两侧分别插入loxP位点,构建Cxcr3-Flox小鼠。该flox小鼠可与组织特异性Cre工具鼠交配,获得在特定细胞类型或组织中敲除Cxcr3基因的小鼠模型。 *使用本品系发表的文献需注明: Cxcr3-Flox mice (Cat. NO. NM-CKO-2117369) were purchased from Shanghai Model Organisms Center, Inc.. ...
International Journal of Molecular Sciences Article Inhibitory Effect of Alisma canaliculatum Ethanolic Extract on NF-κB-Dependent CXCR3 and CXCL10 Expression in TNFα-Exposed MDA-MB-231 Breast Cancer Cells Jihye Choi 1, Sung Shin Ahn 1, Yoongho Lim 2, Young Han Lee 1,3 ID and Soon ...