CD8+T cellsCXCR3CXCL10IFNγICAM-1Lung cancerPD-L1STAT3RadiotherapyRadiotherapy (RT) not only damages tumors but also induces interferon (IFN) expression in tumors. IFNs mediate PD-L1 to exhaust CD8+T cells, but which also directly impact tumor cells and potentially activate anti-tumor immune ...
In vitro and in vivo studies showed that IRF-1 increased CD8 T cells, NK and NKT cells migration, and activated IFN-纬 secretion in NK and NKT cells to induce tumor apoptosis through the CXCL10/CXCR3 paracrine axis. Conversely, this effect was markedly abrogated in HCC tumor bearing mice ...
for signaling throughCXCR3and CXCR4 through sequestering and degrading CXCL11 and CXCL12. CXCR7 may, therefore, not only modulate the activity of CXCR3 and CXCR4 in tumor cell development and metastasis and tissue invasion but also orchestrate the migration of hematopoietic cells in the bone ...
When bone marrow-derived DC were incubated with CXCL10 and RSV, an up-regulation of type I IFN was observed. In addition, T lymphocytes were also examined and a significant decrease in the number of RSV M2 peptide-specific CD8+ T cells was identified. These findings highlight a previously ...
CXCL11 (CXC motif ligand 11) also known as ITAC (interferon-inducible T-cell alpha chemoattractant) (Cole et al.1998) CXCL9, CXCL10, and CXCL11 are structurally related and belong to the non-ELR subfamily of the CXC chemokines. In contrast to the ELR subgroup, the non-ELR subgroup ch...
when inflammation is localized, such as the tumor microenvironment with a T cell infiltrate consisting of tumor-specific and nonspecific T cells18. The mechanisms that would allow bystander activation of memory T cells in such a scenario and the biological consequences of bystander activation are ...
CXCR3 directs the temporal and spatial migration of activated T cells and natural killer cells towards sites of high expression of its native ligands, the INF-γ inducible proteins, C-X-C chemokine ligands 9 (CXCL9), CXCL10, and CXCL11 [16, 17] creating an inflammatory environment. Both...
In addition, higher frequency of CXCR3+ regulatory T cells in ovarian tumors can inhibit effector T responses to promote tumor progression [7]. In contrast, CXCR3-dependent anti-tumor activity has been found in vitro and in vivo and CXCL11 through the CXCR3 can attract CD8+ cytotoxic T ...
Recent studies suggest that the chemokine receptor CXCR3 and the corresponding chemokine ligands CXCL9, CXCL10 and CXCL11 are expressed during CNS diseases and modulate glial functions like migration of microglia or cytokine synthesis [17–26]. CXCR3 ligands in CNS diseases are produced by infiltra...
The binding of CXCL11 to CXCR3 on CD8+ T cells augmented their cytotoxic activity. In a mouse tumor model, the suppressive effect of CD8+ T cells on tumor growth was dependent on CXCR3 expression. Conclusion These findings illustrate that SCD not only orchestrates the differentiation of T ...