肿瘤细胞表达的PD-L1可结合T细胞表面的PD-1,使T细胞失去识别和打击肿瘤细胞的能力。为研究PD-1基因敲除的T细胞治疗结肠癌的有效性,研究人员采用CT26细胞(结肠
PD-L1 and CLAUDIN 18.2 gene humanized CT26 cell line Strain State Construction *Literature published using this strain should indicate: CT26-hPD-L1/hCLAUDIN 18.2 cell line (Cat. NO. NMC-230112) was purchased from Shanghai Model Organisms Center, Inc.. ...
与内源免疫不同，合成免疫可以使免疫原性差的癌症产生抗肿瘤免疫。不过合成免疫也常导致PD-L1表达的增加，反过来抑制合成免疫的效果[13]。另一方面，内源免疫能够激活多种特异性免疫反应，可以形成持久的抗肿瘤反应，这是合成免疫不一定能够做到的。合理猜测，内源免疫与合成免疫可能存在相辅相成的作用。不过这两者能否...
Programmed Cell Death Protein 1(PD-1) ,一种在激活的 T 细胞上表达的受体,与其 配体 PD-L1 和 PD-L2 结合,负向调节免疫反应。 PD-1 配体存在于大多数癌症中,PD- 1:PD-L1/2 相互作用会抑制 T 细胞活性,并使癌细胞逃避免疫监视。 PD1/PDL1 信号转导通 路是肿瘤免疫抑制的重要组成部分,可以抑制 T ...
The humanized hPD-L1 syngeneic clonal colon carcinoma CT26 cell line expresses high levels of human PD-L1 and forms solid tumors in vivo
GDF15/PD-L1基因双人源化的CT26小鼠结肠癌细胞系 品系状态 构建中 *使用本品系发表的文献需注明: CT26-hGDF15/hPD-L1 cell line (Cat. NO. NMC-230015) was purchased from Shanghai Model Organisms Center, Inc.. 相关品系 MC38-hIL1β 细胞系名称:MC38-hIL1β ...
同时采用小鼠结肠腺癌CT26细胞系肝转移模型,通过肿瘤细胞脂质体转染PD-L1反义寡核苷酸、腹腔注射PD-L1反义寡核苷酸两种方式,观察PD-L1反义寡核苷酸处理后结肠癌CT26细胞肝脏转移癌结节数量的变化。 结果:1. 55例大肠癌组织中,PD-L1阳性表达29例(29/55,52.7%),明显高于对照肠黏膜(1/10,10%),χ~2检验,差异具...
PD-L1与CLAUDIN 18.2基因人源化的CT26小鼠结肠癌细胞系 品系状态 构建中 *使用本品系发表的文献需注明: CT26-hPD-L1/hCLAUDIN 18.2 cell line (Cat. NO. NMC-230112) was purchased from Shanghai Model Organisms Center, Inc.. 相关品系 MC38-hPD-L1/hCLAUDIN 18.2 ...
Humanized PD-1 Mice Humanized PD-L1 Mice NMG Mice Other Models Rats Humanized Drug Targets Immunodeficient Diseases Reporters Cre-drivers Standard Strains Inbred Outbred Cells Reporter-labeled Primary Humanized Drug Targets Wild-type Others Supporting Solutions Colony Managemen...
PD-L1MICROENVIRONMENTRADIOTHERAPYRESISTANCEOVERCOMEIMMUNITYThe effects of radiation therapy (RT) for cancer can be systemic and partially mediated by the immune system. However, radiation alone is unlikely to transform an immunosuppressive environment into an immunostimulatory one....