PD-L1 and CLAUDIN 18.2 gene humanized CT26 cell line Strain State Construction *Literature published using this strain should indicate: CT26-hPD-L1/hCLAUDIN 18.2 cell line (Cat. NO. NMC-230112) was purchased from Shanghai Model Organisms Center, Inc.. ...
肿瘤细胞表达的PD-L1可结合T细胞表面的PD-1,使T细胞失去识别和打击肿瘤细胞的能力。为研究PD-1基因敲除的T细胞治疗结肠癌的有效性,研究人员采用CT26细胞(结肠
这里所说的两类免疫治疗，第一大类是以PD-1/L1抑制剂为代表的，驱动内源性免疫细胞的内源免疫治疗。这种方法很大程度上依赖于已经存在的特异性识别癌细胞的CD8+T细胞，通过免疫治疗增强其抗肿瘤活性。但并不是所有的癌种都存在足够供内源性细胞识别的抗原，有的癌种还会利用MHC下调来逃避免疫。这种情况下便出现了...
The humanized hPD-L1 syngeneic clonal colon carcinoma CT26 cell line expresses high levels of human PD-L1 and forms solid tumors in vivo.Applications & Features Resources Validation Data Contact Us Design of the genO-CT26-hPD-L1 cell line The CT26.WT cell line was derived and subcloned from...
CT26-hPD-L1/hCLAUDIN 18.2 导出PDF 品系基本信息 细胞系名称 CT26-hPD-L1/hCLAUDIN 18.2 目录号 NMC-230112 品系描述 PD-L1与CLAUDIN 18.2基因人源化的CT26小鼠结肠癌细胞系 品系状态 构建中 *使用本品系发表的文献需注明: CT26-hPD-L1/hCLAUDIN 18.2 cell line (Cat. NO. NMC-230112) was purchased from...
同时采用小鼠结肠腺癌CT26细胞系肝转移模型,通过肿瘤细胞脂质体转染PD-L1反义寡核苷酸、腹腔注射PD-L1反义寡核苷酸两种方式,观察PD-L1反义寡核苷酸处理后结肠癌CT26细胞肝脏转移癌结节数量的变化。 结果:1. 55例大肠癌组织中,PD-L1阳性表达29例(29/55,52.7%),明显高于对照肠黏膜(1/10,10%),χ~2检验,差异具...
CT26-Cd274em1(hPD-L1)Cd86em1(hCD86)Smoc 目录号 NM-S24A-TM43 品系描述 PD-L1/CD86基因双人源化的CT26结肠癌细胞系 品系状态 表达验证完成 *使用本品系发表的文献需注明: CT26-hPD-L1/hCD86 cell line (Cat. NO. NM-S24A-TM43) was purchased from Shanghai Model Organisms Center, Inc.. ...
Humanized PD-1 Mice Humanized PD-L1 Mice NMG Mice Other Models Rats Humanized Drug Targets Immunodeficient Diseases Reporters Cre-drivers Standard Strains Inbred Outbred Cells Reporter-labeled Primary Humanized Drug Targets Wild-type Others Supporting Solutions Colony Managemen...
we provide a comprehensive overview of the pleiotropic roles of ILC2s in diklerent tumor settings. Furthermore, we discuss how diklerent therapeutic approaches targeting ILC2s could improve the eklicacy of current tumor immunotherapies.Immune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies...
PD-L1 and CLAUDIN 18.2 gene humanized CT26 cell line 品系状态 构建中 *使用本品系发表的文献需注明: CT26-hPD-L1/hCLAUDIN 18.2 cell line (Cat. NO. NMC-230112) was purchased from Shanghai Model Organisms Center, Inc.. 相关品系 MC38-hPD-L1/hCLAUDIN 18.2 细胞系名称:MC38-hPD-L1/hCLAUD...