肿瘤细胞表达的PD-L1可结合T细胞表面的PD-1,使T细胞失去识别和打击肿瘤细胞的能力。为研究PD-1基因敲除的T细胞治疗结肠癌的有效性,研究人员采用CT26细胞(结肠
Results In the CT26.wt model, tumor growth was suppressed by mTFF2-MSA, anti-PD-1 and by the combination of mTFF2-MSA/anti-PD-1 by 16%, 40% and 60%, respectively. Survival in the CT26.wt model on Day 30 treated with vehicle, mTFF2-MSA, anti-PD1 and the combination of mTFF2-...
In the CT26.wt model, administration of TFF2-MSA alone exhibited little effect, but the combination of anti-PD-1 and TFF2-MSA showed a profound effect. In the CT26.wt model, administration of TFF2-MSA suppressed tumor growth (TGI 17%), anti-PD-1 alone (TGI 43%) and the combination...
Given the increased expression of immunosuppressive factors, such as PD-L1 and TGF-尾, we assessed the effect of early introduction of immunotherapy in combination with chemotherapy. We found that mice treated with cytokine induced killer cells and PD-L1 monoclonal antibodies after one cycle of 5-...
Programmed cell death 1 ligand 1 proteinRadio-frequency therapyTumor microenvironmentsPD-L1MICROENVIRONMENTRADIOTHERAPYRESISTANCEOVERCOMEIMMUNITYThe effects of radiation therapy (RT) for cancer can be systemic and partially mediated by the immune system. However, radiation alone is...