Abstract 704: MDSC-targeted TFF2-MSA suppresses tumor growth and increases survival in anti-PD-1 treated MC38 and CT26.wt murine colorectal cancer modelsdoi:10.1158/1538-7445.AM2023-704Aims: Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment are a potential therapeutic target ...
癌症药物的发现依赖于临床前研究模型。从药物的发现、作用机制的厘清、给药方法的探索再到安全性管理，实验室工作不可或缺，CTLA-4和PD-1的故事就是最好的例证。但我们都清楚，临床前模型是无法完全反映人体免疫真实情况的。不空谈理论，举两个实例：常用的鼠结直肠癌模型MC38，它的高肿瘤突变负荷（TMB）能够反应...
CT26 MC38 EL4 PD-1 PD-L1 genO-hPD‑1/hCTLA‑4 The genO‑hPD-1/hCTLA-4 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint PD-1 and/or CTLA-4 in fully immunocompetent mice. genO-hPD‑1/hGITR/hGITRL The ...
Cell Line:MC38-hPD-L1/hCLAUDIN 18.2 Cat. NO.:NMC-230113 You may also like Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license ...
和抗PD-L1抗体的疗效,并研究其疗效的分子机制,以期为增强ICI疗效提供新的联合策略.方法使用MC38,CT26两种小鼠CRC细胞建立动物皮下瘤模型,评估ATRi,IR和抗PD-L1... 刘超凡,王曦,秦婉,... - 《Chinese Journal of Cancer》 被引量: 0发表: 2023年 CRISPR/CAS9敲除PD-1的肿瘤浸润T淋巴细胞回输对小鼠结肠癌的...
日本語 한국어 Cart0 Models CT26-hGDF15(NEO) Export PDF Strain Information Cell Line CT26-hGDF15(NEO) Cat. NO. NMC-230082 Model Description GDF15 gene humanized MC38 cell line Strain State Construction *Literature published using this strain should indicate: CT26-hGDF15(NEO) cell line...
例如,结直肠MC38细胞系存在微卫星-不稳定表型( MSI )可形成T细胞炎症的肿瘤微环境,以其对ICB的强大反应。另一方面,结直肠癌CT26细胞系存在微卫星稳定( MSS )模型形成非T细胞炎症肿瘤微环境,且其对ICB反应差。MC38和CT26系的免疫表型特征和对ICB的反应性与临床观察到的MSI和MSS结直肠癌患者的相同。