Single particle cryo em is a powerful structural biology technique for 3D characterization of proteins, protein complexes and macromolecules at near-atomic and atomic resolution.
Single particle cryo-EM or single particle analysis is an increasingly popular cryo-EM technique that allows you to investigate biomolecules at near- and atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies. In single particle cryo-E...
Structure based rational drug design Cryo-EM can enable you to visualize molecules across a range of sizes and can help you obtain time-critical insights for your drug discovery projects. For Research Use Only. Not for use in diagnostic procedures. ...
Single particle cryo em is a powerful structural biology technique for 3D characterization of proteins, protein complexes and macromolecules at near-atomic and atomic resolution.
Cryo-electron microscopy (cryo-EM) has emerged as a potent technique for determining the structure and functionality of biological macromolecules. However, limited by the physical imaging conditions, such as low electron beam dose, micrographs in cryo-EM typically contend with an extremely low signal...
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structures of biological macromolecular complexes. Picking single-protein particles from cryo-EM micrographs is a crucial step in reconstructing protein structures. However, the widely used template-based particle picking process...
Single-particle cryo-electron microscopy (cryo-EM), is an increasingly popular technique used by structural biologists to solve structures at atomic resolution. This technique complements x-ray crystallography because it reveals structural details without the need for a crystalline specimen. Through the ...
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies. Historically, its potential for application in drug discovery has been heavily limited by two issues: the minimum ...
Cryo-electron microscopy (cryo-EM) is an increasingly important technique to elucidate the structure of large macromolecular assemblies such as whole viruses. Cryo-EM generally does not provide atomic resolution information, but numerous sub-nanometer resolution structures have been reported in the last ...
The drug discovery field has watched with (initial) skepticism and wonder at the progression of the technique and how it revolutionized the molecular understanding of previously intractable targets. This article critically assesses how cryo-EM has impacted drug discovery in diverse therapeutic areas. ...