Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation[J]. Science, 2020, 367(6483):eabb2507. 案例2:生命剪接体 Cryo-EM别适用于解析难以结晶的大分子复合物的高分辨率三维结构。通过在近生理状态下观察蛋白质和其他生物大分子,Cryo-EM 揭示了它们的功能和动态变化。如图2所示,中国科学院...
参考文献:Wrapp D , Wang N , Corbett K S , et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation[J]. Science, 2020, 367(6483):eabb2507. 案例2:生命剪接体 Cryo-EM别适用于解析难以结晶的大分子复合物的高分辨率三维结构。通过在近生理状态下观察蛋白质和其他生物大分子...
融合前构象中 2019-nCoV 尖峰的冷冻电镜结构 nCoV 三聚体尖峰的结构世界卫生组织已宣布新型冠状病毒 (2019-nCoV) 的爆发为国际关注的突发公共卫生事件。该病毒通过其三聚体刺突糖蛋白与宿主细胞结合,使该蛋白成为潜在治疗和诊断的关键目标。瓦普等人。通过冷冻电子显微镜确定了 2019-nCoV 三聚体刺突蛋白的 3.5 埃分辨...
参考文献:Wrapp D , Wang N , Corbett K S , et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation[J]. Science, 2020, 367(6483):eabb2507. 案例2:生命剪接体 Cryo-EM别适用于解析难以结晶的大分子复合物的高分辨率三维结构。通过在近生理状态下观察蛋白质和其他生物大分子...
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Science 2020 Wrapp, D.; Wang, N.; Corbett, K. S.; Goldsmith, J. A.; Hsieh, C. -L.; Abiona, O.; Graham, B. S.; McLellan, J. S. Resources Related materials ...
The omicron variant of SARS-CoV-2 has been spreading rapidly across the globe. The virus-surface spike protein plays a critical role in the cell entry and immune evasion of SARS-CoV-2. Here we determined the 3.0 Å cryo-EM structure of the omicron spike protein ectodomain. In contrast...
教材定位:可以看Getting started in cryo-EM这门课程,电子教材:Electron Microscopy 待续~ 参考: 2017,诺贝尔奖,THE DEVELOPMENT OF CRYO-ELECTRON MICROSCOPY 施一公 博士 Nieng Yan 颜宁 Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation...
Cryo-EM structure of the large subunit of the spinach chloroplast ribosome. Sci. Rep. 6, 35793 (2016). Article CAS PubMed PubMed Central Google Scholar Wrapp, D. et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367, 1260–1263 (2020). Article ...
Wrapp D, Wang N, Corbett KS et al (2020) Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science (80–) 367:1260–1263 CAS Google Scholar Xia D, Yu CA, Kim H et al (1997) Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Scienc...
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367, 1260–1263 (2020). Article CAS PubMed PubMed Central Google Scholar Wrobel, A. G. et al. SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects. ...