Tumor antigen presentation requires cross-presentation of antigens from the tumor cells by DC. Dendritic cells capture antigens from tumor cells into endosomal compartments and process them. Then they expose at their cell surface their own MHC class I molecules complexed with tumor cell epitopes, ...
Cross-presentation of antigens by dendritic cells: Role of autophagy Commentary on: Mintern et al. Differential use of autophagy by primary dendritic cells specialised in cross-presentation. Autophagy. 2015; 11:906-17. M Das,SV Kaveri,J Bayry - 《Oncotarget》 被引量: 5发表: 2015年 ...
CD8+ T cells specific to at least two influenza antigens FluM1 and NS1 can be detected in the blood of mice vaccinated with FluMist but not in mice vaccinated with Fluzone. Specific T cells are also present in the spleen and peripheral tissues (lung) demonstrating that human T cells can...
Live Long and Prosper for Antigen Cross-Presentation.###Differential use of autophagy by primary dendritic cells specialized in cross-presentation.###Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens.###[Stereotactic radiotherap...
cross-presentation cross-priming cancer immunotherapy dendritic cells T cells Introduction In a series of experiments involving immunization with major histocompatibility complex (MHC)-incompatible mouse splenocytes osmotically loaded with chicken ovalbumin (OVA), Michael Bevan discovered that the antigen-pre...
Antigen capture is believed to occur by phagocytosis of antigen-bearing dead cells. Recent studies suggest that the antigen transferred from the phagocytosed cell to the DC during cross presentation is a proteasome substrate, rather than a proteasomal degradation product. In most cases, the ...
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic...
Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8+T cells. cDC1 cells can be identified in mice and humans by high expression of DNGR-1 (also known as CLEC9A), a receptor that binds dead-cell debris and facilitates XP...
Dendritic cells (DCs) are the main professional antigen-presenting cells for induction of T-cell adaptive responses. Cancer cells express tumor antigens, including neoantigens generated by nonsynonymous mutations, but are poor for antigen presentation and for providing costimulatory signals for T-cell ...
The efficiency of antigen cross-presentation, which is the presentation of extracellular antigens on MHC I molecules, critically depends on the stability of the internalized antigens. Since rapid degradation within the lysosomal compartment impairs cross-presentation, potent cross-presenting cells display ...