Second, we discuss mechanisms of cross-presentation, the phenomenon whereby extracellular and luminal protein antigens can be processed by antigen-presenting cells, particularly dendritic cells, and presented by MHC class I molecules to CD8(+) T cells. The focus of the discussion is mainly on the...
Intracellular molecular players in cross-presentation Evidence for cross-presentation and cross-priming in cancer immunology Does T-cell cross-priming take place in the TME and/or in tumor-draining LNs? Immunosuppressive factors for DCs in the TME Immunogenic cell death and cross-priming Targeting tum...
Cross-presentation of the oncofetal tumor antigen 5T4 from irradiated prostate cancer cells: a key role for Hsp70 Immune responses contribute to the success of radiation therapy of solid tumors; however, the mechanism of triggering CD8+ T cell responses is poorly understood. Antigen cross-presentat...
The efficiency of antigen cross-presentation, which is the presentation of extracellular antigens on MHC I molecules, critically depends on the stability of the internalized antigens. Since rapid degradation within the lysosomal compartment impairs cross-presentation, potent cross-presenting cells display ...
This process is known as cross-presentation. It provides a mechanism that can drive dendritic cells to generate either tolerance to self-antigens or immunity to pathogens. The cells responsible for, and mechanisms underlying, this decision between tolerance and immunity via cross-presentation has ...
whereas the second is more stable and favours MHC-I presentation. The endocytosis route depends on the mechanism of Ag uptake. The soluble ovalbumin (sOVA) model has been studied in detail. If internalised by the mannose receptor, sOVA is routed towards stable, early endosomes. In contrast, ...
Antigen processing and presentation is the mechanism by which whole antigens are degraded and loaded onto MHC molecules for display on the cell surface for recognition by T cells. Both macrophages and dendritic cells (DCs) are considered professional antigen-presenting cells, although DCs possess the...
Recent studies suggest that the antigen transferred from the phagocytosed cell to the DC during cross presentation is a proteasome substrate, rather than a proteasomal degradation product. In most cases, the formation of the peptide-MHC class I complexes in DCs requires the export of protein ...
Cross presentationMHC class IPhagosomesProteasomeDendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8 + T lymphocytes after migration to the draining lymph nodes. This process, called "cross ...
Live Long and Prosper for Antigen Cross-Presentation.###Differential use of autophagy by primary dendritic cells specialized in cross-presentation.###Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens.###[Stereotactic radiotherap...