Cross-presentation of antigens by dendritic cells: Role of autophagy Commentary on: Mintern et al. Differential use of autophagy by primary dendritic cells specialised in cross-presentation. Autophagy. 2015; 11:906-17. M Das,SV Kaveri,J Bayry - 《Oncotarget》 被引量: 5发表: 2015年 ...
Tumor antigen presentation requires cross-presentation of antigens from the tumor cells by DC. Dendritic cells capture antigens from tumor cells into endosomal compartments and process them. Then they expose at their cell surface their own MHC class I molecules complexed with tumor cell epitopes, ...
Cross-presentation of Influenza virus vaccine antigens to CD8+ T cells in humanized miceCritical to the development of novel vaccines is the availability of in vivo models of the human immune system that permit testing of vaccine efficacy. Here, we used NOD/SCID beta2m / immunodeficient mice ...
The efficiency of antigen cross-presentation, which is the presentation of extracellular antigens on MHC I molecules, critically depends on the stability of the internalized antigens. Since rapid degradation within the lysosomal compartment impairs cross-presentation, potent cross-presenting cells display ...
Live Long and Prosper for Antigen Cross-Presentation.###Differential use of autophagy by primary dendritic cells specialized in cross-presentation.###Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens.###[Stereotactic radiotherap...
of Multiple Tumor Antigens Role of C-type Lectin Receptors Other Routes of Antigen Entry for Crosspresentation Processing of the Antigenic Cargo Nature of the Antigenic Cargo Regulation of Crosspresentation during Dendritic Cell Maturation Role of Dendritic Cell Subsets in Crosspresentation Some ...
Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8+T cells. cDC1 cells can be identified in mice and humans by high expression of DNGR-1 (also known as CLEC9A), a receptor that binds dead-cell debris and facilitates XP...
Cross presentationMHC class IPhagosomesProteasomeDendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8 + T lymphocytes after migration to the draining lymph nodes. This process, called "cross ...
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic...
V Schuette,S Burgdorf 摘要: The efficiency of antigen cross-presentation, which is the presentation of extracellular antigens on MHC I molecules, critically depends on the stability of the internalized antigens. Since rapid degradation within the lysosomal compartment impairs cross-presentation, potent...