Proteins are key players in the complex world of living cells. No matter whether they are involved in enzymatic reactions, inter-cell communication or nume... G Studer 被引量: 0发表: 2017年 Standing on the shoulders of giants: James Watson, Francis Crick, Maurice Wilkins, Rosalind Franklin ...
DIBs allow biomolecular sensing and direct detection of transmembrane proteins or peptides and small molecules such as drugs, anesthetics, or even ions. Cell-free expression systems allow in vitro protein synthesis using actual natural machinery extracted from organisms (Fig. 1B). Previous attempts ...
As an initial goal, we wanted to increase sTyr production in these cells in order to optimize its availability for incorporation into proteins. Since NnSULT1C1 utilizes tyrosine and PAPS for producing sTyr, we quantified sTyr production in five knockout E. coli cell lines in which the gene ...
cellcyclekinetochorescohesinsisterchromatidsDuring the meiotic cell cycle, a single round of DNA replication precedes two nuclear divisions. Recent work has shown that the proteins controlling the mitotic cell cycle are either replaced by homologous proteins only expressed during the meiotic cell cycle ...
The Gene Ontology Annotation (GOA) resource (http://www.ebi.ac.uk/GOA) provides evidence-based Gene Ontology (GO) annotations to proteins in the UniProt Kn... RP Huntley,S Tony,MM Prudence,... - 《Nucleic Acids Research》 被引量: 357发表: 2015年 ...
Chemically synthesised small antibody mimetics (maximally around 120 aa in peptide length1) that specifically bind to the same epitopes as their parental monoclonal antibody (mAb) drugs provide promising options for molecular-targeted therapies. Low-molecular-weight proteins have good tissue penetration, ...
Many experts say that studying epigenetics may lead to a clearer understanding of age-related diseases such as cancer, since the changes lie not in the DNA itself, but rather the surrounding chemicals that make proteins and even facilitate new cell growth, including the cells that make up sperm...
In both cases, these split intein groups enable the production of large proteins that make the synthetic spider silk tougher and stronger and the mussel foot proteins stickier. In this case, they enable the construction of novel nanostructures. ...
In Prp2 , there was only one deletion of two tandem repeats. These deletions occur within the coding regions in a manner that conserves the reading frame. The results are the first description of genetic variation in cell wall proteins and its molecular basis. The nature of these genetic ...
In the human bodycellsturn genes on and off by means of chemical modifications that change DNA and related proteins. These epigenetic changes are continuous and are at the core of how healthy cells transform into cancer cells. These modifications contribute to a tumor's ability to grow indefinite...