Many neuronal proteins undergo lipid modification that regulates their function and subcellular localization. One such modification is palmitoylation, whic... Dalva,B M. - 《Journal of Cell Biology》 被引量: 27发表: 2009年 Simple electrostatic model improves designed protein sequences Electrostatic inte...
Recent studies show that nuclear lamins, the type V intermediate filament proteins, are required for proper building of at least some organs. As the major structural components of the nuclear lamina found underneath the inner nuclear membranes, lamins are ubiquitously expressed in all animal cells. ...
confidence interacting networks with NPHP/JBTS/MKS proteins and discovered 800 proteins in connected protein modules that function (1) at the ciliary base; (2) at centrosomes; (3) in the pericentriolar material; and (4) around the ciliary axoneme, suggesting how proteins are tra...
Empress gained material confidence in its mission during the past year, when the company used its platform to create a dozen new small molecule candidates for its own pipeline development — with significant results. “We’ve been putting our compounds through the same battery of tests that every...
5It has long been suspected that cancers with a greater number of gene mutations may provoke a stronger antitumor immune response. The thinking behind this hypothesis relates to the production of neoantigens—fragments of proteins expressed on the surface of cancer cells that are encoded by mutated...
In fluorescence microscopy, fluorescent dyes or proteins are used to label specific structures or molecules within a sample. The basic principles of fluorescence microscopy involve illuminating the...Browse Cameras & Imaging, Lasers, Optical Components, Test & Measurement, and more. AmericasAydogan ...
To figure out whichhuman geneswere impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA and used the information to identify which genes originated...
The 2018 Nobel Prize in Chemistry went to three scientists who developed the method that forever changed protein engineering: directed evolution. Mimicking natural evolution, directed evolution guides the synthesis of proteins with improved or new functi
Shaped like a kind of knobby tube, the EMC acts as a gateway between the interior of the cell and the cell’s outer membrane, and behaves as a kind of border control through which only certain proteins can pass. The EMC interacts with proteins involved in a wide range of import...
What determines the proteins that DNA will code for? What acts as the template in DNA replication? What is branched DNA? How does the structure of DNA allow cells to replicate? What provides the energy for DNA synthesis? What is at the end of a DNA strand? What is the process of DNA...