描述: CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) 表现出对 CRBN 的抑制作用。存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year溶解度: DMSO : 65 mg/ml (214.36 mM)关键字: N (2,6 dioxopiperidin 3 yl) 4 nitrophthalimide | N...
Ligand for cereblon (CRBN)Compounds with immunomodulatory activity, methods of producing the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysfunctional protein activity. Is disclosed. [Selection ...
XY-E10069【中文名称】人CXC趋化因子配体16(CXCL16)ELISA试剂盒品牌【英文名称】Human CXC-chemokine ligand 16,CXCL16 ELISA试剂盒多少钱 XY-E10070【中文名称】人CXC趋化因子受体3(CXCR3)ELISA试剂盒品牌【英文名称】Human CXC-chemokine receptor 3,CXCR3 ELISA试剂盒多少钱 ...
Genetic mutations, especially those in genes encoding subunits of voltage-gated and ligand-gated ion channels including BK channels, often alter channel functions and induce epilepsy1,2, one of the most common chronic neurological disorders found in people of all ages3. BK channels are formed by ...
2429878-72-6 英文名: 7-Octynoic acid, 8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]- 英文别名: Lenalidomide-acetylene-C5-COOH;Cereblon ligand-linker Conjugate;8-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]oct-7-ynoic acid;8-(2-(2,6-Dioxopiperidin...
PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader. ChemeGen 作为优秀的抑制剂、激动剂及新型生命科学试剂的供应商,致力于为广大科研、商业实验室的科学研究者提供...
An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity Sang-Youl Park Jingde Qiu Sean R. Cutler Nature Chemical Biology (2024) Possible New Candidates Involved to Thalidomide-Related Limbs and Cardiac Defects: A Systems Biology Approach Bruna Duarte Rengel Lavínia ...
Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases...
Using apoptosis model and combination analyses, we found that pomalidomide directly targeted ETFA, and increased ATP generation, thereby significantly promoting tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Specific knockdown of ETFA could effectively eliminate the ...
产品名称:Thalidomide-5-OH CAS:64567-60-8 产品介绍:Thalidomide-5-OH is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC. 品牌介绍: ...