以配体为基(ligand-based)的药物设计乃是因为受体(target protein)结构尚未被解出亦或无法得知,因而以活性配体的结构作分 …ir.lib.nctu.edu.tw|基于5个网页 2. 以配位体为基础 最后,我们以配位体为基础 (ligand-based) 探讨28个先导化合物的结构与活性关系。透过3D-QSAR的工具,包含CoMFA (Comp…nthur.lib....
Created with:Release 2018-1Prerequisites:Release 2017-3 or higherIntroduction to Structure Preparation and VisualizationFiles Required:phase_tutorial.prjzipCategories:Ligand-Based Design, Structure-Based DesignKeywords:Pharmacophore, hypothesis, Phase database, congeneric ligands, diverse ligands, binding mode ...
We have identified thirty-one advanced clinically effective GSK-3 ligands, which have been used to establish ligand-based three-dimensional pharmacophore to know the essential features of glycogen synthase kinase inhibitors. Pharmacophore model was built based on known glycogen synthase kinase inhibitors ...
1) Ligand-based drug design 基于配体的药物设计2) substrate based design 基于底物的药物设计 1. In recent years, three methods of molecular design have been developed, including substrate based design,structure based design and combinatorial chemistry technology. 近年来 ,科学家们发展了三种分子设计...
In this study, we developed a novel adoptive T-cell therapy for ovarian cancer based on a chimeric antigen receptor structure. We used a ligand-receptor binding motif to enhance the therapeutic effect of targeting CA125. Since mesothelin can naturally bind to CA125 with high affinity, we concat...
ligand－based strategy是什么意思 发自小木虫Android客户端
In a lot of cases, ligand-based drug design and structure-based drug design can be applied together to develop potent drug candidates. These methods have been applied in different stages and aspects in the research and development at HitGen and benefitted multiple projects....
Ligand-based pharmacophore Drug repurposing Fluoroquinolone Virtual screening Antimicrobial compounds ZINCpharmer Chemical scaffold 1. Introduction Antibiotics have helped to revolutionize healthcare by efficiently treating bacterial infections, saving countless lives since their discovery [1]. However, overuse and...
Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies Anton Lindberg, Emily Murrell, Junchao Tong, N. Scott Mason, Daniel Sohn, Johan Sandell, Peter Ström, Jeffrey S. Stehouwer, Brian J. Lopresti, Jenny Viklund, Samuel Svensson, Ches...
Evolution of adrenal and sex steroid action in vertebrates: a ligand-based mechanism for complexity Various explanations have been proposed to account for complex differentiation and development in humans, despite the human genome containing only two to t... ME Baker - 《Bioessays》 被引量: 110发...