CPSF6 is a component of the CFIm complex, involved in mRNA 3鈥瞖nd processing. Despite increasing interest on this protein as a consequence of proposed roles in cancer and HIV infection, several aspects of CPSF6 biological function are poorly understood. In this work we studied the expression...
Disrupting CR-HDAC3 interaction, restores PU.1 expression and myeloid differentiation. Furthermore, HDAC inhibitors effectively suppress CR-driven leukemia in vitro and in vivo. Hence, our data reveals the molecular bases of oncogenic CR fusion and provides a potential therapeutic approach against AML...
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analysis of transiently transfected HeLa cells revealed that wild-type MxB localized to the nuclear membrane and was also found in cytoplasm as the same seen in Additional file1a. There was a significant degree of colocalization between MxB and NUP358. However, deletion of the NLS resulted in c...
However, the signaling pathway and molecular mechanism underlying the downregulation of the CPSF6 protein remain elusive. Here, we found that MAVS triggers the nuclear import of the E3 ligase SYVN1 mediated by NUP153 in response to vesicular stomatitis virus infection. Then, SYVN1 catalyzes K48-...
These firms narrowly lost the contest and are hence very similar, before VC financing, to the VC backed firms; self-selection is specifically taken into account. In line with previous results, Italian startups financed by VC reach a larger size and become more innovative than other startups....
Alternative polyadenylation (APA), an RNA processing mechanism that results in mRNA with distinct 3' termini, is a rapidly expanding area of research that in recent studies has been linked to the mechanistic target of rapamycin (mTOR) signaling pathway, a key regulatory pathway in physiology and ...
CPSF6 and NUP153 bind a multi-subunit interface in HIV-1 hexamer.Amanda J. PriceDavid A. JacquesWilliam A. McEwanAdam J. FletcherSebastian EssigJason W. ChinUpul D. HalambageChristopher AikenLeo C. James
CPSF6 is a component of the CFIm complex, involved in mRNA 3'end processing. Despite increasing interest on this protein as a consequence of proposed roles in cancer and HIV infection, several aspects of CPSF6 biological function are poorly understood. In this work we studied the expression ...
Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent mannerdoi:10.1101/2020.06.05.136697Zhou ZhongJiying NingEmerson A. BoggsSooin JangCallen WallaceCheryl TelmerMarcel P. BruchezJinwoo AhnAlan N. Engelman...