Borini Etichetti, Carla M.Tenaglia, AlbanoNicol Arroyo, MariaGirardini, Javier E.Consejo Nacl Invest Cient &Gene Expression Patterns: A Section of Mechanisms of Development
A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway We showed that CFIm components, CPSF6 and NUDT21, promote the short Trim9/TRIM9 isoform (Trim9-S/TRIM9-S) expression. In addition, we identified ... RS Herron,AK Kunisky,JR Madd...
However, the role of XBP1 and its spiced isoform (XBP1s) in regulating DDP resistance of LUAD cells remains to be investigated. Alternative polyadenylation (APA) is a widespread post-transcriptional mechanism of gene regulation at the mRNA level (Tian and Manley, 2017). According to the ...
Efficient regulatory manners are needed to modulate the strength and duration of the response and recover initial state. APA, a widespread gene regulatory mechanism in eukaryotes that generates messenger RNA isoforms with different 3' UTR lengths, has emerged as a key...