To deepen our knowledge about circ-ZNF609 role in cell cycle regulation, we studied its expression and function in rhabdomyosarcoma (RMS), a pediatric skeletal muscle malignancy. We found that circ-ZNF609 is upregulated in biopsies from the two major RMS subtypes, embryonal (ERMS) and alveolar...
In the follow-up test, circZNF609 was discovered to take a bigger proportion in cytoplasm than nucleus in HCC, indicating its post-transcriptional regulation of target gene expression. Thus, we boldly conjectured that circZNF609 might mediate the activation of Hedgehog pathway through post-...
Our results show that the expression of circ-ZNF609 is regulated by RNA N6-methyladenosine (RNA m6A) methylation, whereas RNA m6A demethylase fat mass and obesity associated gene (FTO) acts as the downstream factor of circ-ZNF609 in response to DOX treatment. Knockdown of circ-ZNF609 can ...
Luciferase reporter assay, target gene prediction and screening were used to validate downstream target genes of circZNF609 and miR-134-5p. EGFR expression was detected by Western blot analysis and RT-qPCR. Nude mice were used to detect tumor changes. CircZNF609 was upregulated in LSCC and ...
GENE expressionHEPATOCELLULAR carcinomaVASCULAR endothelial cellsThis retraction relates to this paper Liao X, Zhan W, Tian B, Luo Y, Gu F, Li R. I OncoTargets Ther i . 2020;13:7773-7783. The Editor and Publisher of I OncoTargets and Therapy i wish to retract the published ...
The downstream gene and signalling of cZNF609 were studied by utilizing qRT-PCR and Western blot. Results: HaCaT cells were remarkably damaged by H2O2, as evidenced by the viability loss, apoptosis and ROS generation. It was coupled with the elevated expression of p53, p16, Bax and the ...