InvivoGen provides ODN 2395, a Class C CpG oligonucleotide (ODN) witha preference for the human and mouse Toll-like receptor 9 (TLR9).Class C CpG ODNs, such as ODN 2395,combine classes A and B features. They contain a completephosphorothioate (PS) backbone and a CpG-containing palindromic...
InvivoGen also offers: • TLR reporter cells: HEK293, RAW, THP-1 cells • TLR research tools: Antibodies, Inhibitors, etc. ODN 2395 is a Class C CpG oligonucleotide (ODN), specific for the human and murine Toll-like receptor 9 (TLR9) [1]. It is a short synthetic single-stranded...
1. 作为纳米佐剂注射C57BL6小鼠,ODN 2395 2. 诱导原代人CLL细胞极化和迁移,ODN 2395/ODN 2006 ODN 2088 —TLR 9拮抗剂 通过破坏CpGODNs与TLR9在内涵体囊泡中的共区域化而发挥作用,而不影响细胞结合和摄取。 应用: 1. TLR9抑制剂治疗大鼠疾病模型,ODN 2088 CpG ODN的选择你明白了吗? InvivoGen 1977年成立...
用不同浓度的C-class CpG ODNs, ODN 2395 或 ODN M362及相应的对照ODNs 刺激HEK-Blue™ hTLR9 细胞 (表达人源TLR9和NF-κB诱导 SEAP 报告基因, 刺激物与HEK-Blue Detection试剂共孵育24 小时, NF-ΚB-诱导 SEAP的水平在OD 655 nm检测。 Class C CpG ODNs 刺激 HEK-Blue™ mTLR9 细胞 (货号:mkb...
[0068] 本发明示例性实施例中采用的CpG-ODN为:Class-C CpG-ODN 2395,具有硫代磷酸 酯全修饰的[5’-TCGTCGTTTTCGGCGCGCGCCG-3’],(22mer),InvivoGen(San Diego,CA,USA) 公司出品,产品货号:tlrl-2395-1。 [0069] 传统磷酸铝佐剂( adjuvant):购自InvivoGen(San Diego,CA,USA),货 号vac-phos-250。 [...
本发明示例性实施例中采用的cpg-odn为:class-ccpg-odn2395,具有硫代磷酸酯全修饰的[5’-tcgtcgttttcggcgcgcgccg-3’],(22mer),invivogen(sandiego,ca,usa)公司出品,产品货号:tlrl-2395-1。 传统磷酸铝佐剂(adjuvant):购自invivogen(sandiego,ca,usa),货号vac-phos-250。
CpG ODN, type C (human/mouse) - TLR9-based vaccine adjuvant TLR9 activation with ODN 2395 InvivoGen also offers: •TLR reporter cells:HEK293, RAW, THP-1 cells •TLR research tools:Antibodies, Inhibitors, etc. ODN 2395 VacciGrade™ is a Class C CpG oligonucleotide (ODN),specific for...
ODN 2395 is a type C CpG ODN [7]. References: 1. Krieg AM. et al., 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature, 374(6522):546-9. 2. Bauer S. et al., 2001. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recogni...
InvivoGen offers high-quality CpG ODNs that are functionally tested and guaranteed endotoxin-free to avoid non-specific immune stimulation. The most widely referenced of them are ODN2006, ODN1826 and ODN2216. CpG ODNs of class A, B or C stimulate PBMCs,
2. 诱导原代人CLL细胞极化和迁移,ODN 2395/ODN 2006 ODN 2088 —TLR 9拮抗剂 通过破坏CpGODNs与TLR9在内涵体囊泡中的共区域化而发挥作用,而不影响细胞结合和摄取。 应用: 1. TLR9抑制剂治疗大鼠疾病模型,ODN 2088 CpG ODN的选择你明白了吗? InvivoGen 1977年成立于法国,是法国第一家生物科技公司。公司成立...