CpG 2006 ODN (also known as CpG ODN 7909) is a human TLR9 ligand. InvivoGen's CpG oligonucleotides are functionally tested and guaranteed endotoxin-free to avoid non-specific immune stimulation. The sequence of CpG-B (type K) ODN 2006 (also known as PF-3
CpG 2006 Biotin ODN (also known as CpG ODN 7909 Biotin) is a labeled human TLR9 ligand. InvivoGen CpG oligonucleotides are functionally tested and guaranteed endotoxin-free to avoid non-specific immune stimulation. The sequence of CpG-B (type K) ODN 2006
CpG-ODN:Themodulatorofimmuneresponse ZHENGJian.feng (UnionHospital,TorsiMedicalCollege,HuazhongUniversityofScienceandTechnology, Wuhan430022, China) AbstractToll-likereceptors(TLR)aleprimarilythoughttoplayanimportantroleinrecogniti onofpatho- genandactivationofinnateimmuneresponse,andnOWitisfoundthattheinteractionbet...
用不同浓度的B-class CpG ODNs, ODN 1668, ODN 1826, ODN 2006 或 ODN 2007及相应的对照ODNs 刺激HEK-Blue™ hTLR9 细胞 (表达人源TLR9和NF-κB诱导 SEAP 报告基因, 刺激物与HEK-Blue Detection试剂共孵育24 小时, NF-ΚB-诱导 SEAP的水平在OD 655 nm检测。 Class B CpG ODNs 刺激 HEK-Blue™ ...
The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8+ T-cell responses in vitro Article Open access 15 July 2020 A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies Article Open access 05...
所有CpG‑寡脱氧核苷酸(CpG‑oligodeoxynucleotide ,CpG‑ODN) 均购自 Integrated DNA Technologies,Inc.。CpG‑ODN溶于无DNase/RNase的水中,等量分装储存 于‑20℃。 用于体内治疗的抗PD‑1抗体购自InvivoGen(Cat.No.mpd1‑mab15‑10)。用于免疫 组 织化学的抗小鼠CD8抗体购自Invitrogen(Cat .No ....
The adjuvant activity of synthetic TLR9 ligands was evaluated in various human clinical trials includ- ing malaria (13,30), influenza (31) and hepatitis B. In case of hepatitis B, the vaccine Engerix-B coadministered with CpG ODN significantly improved the antibody response in healthy individuals...
We provided the first in vivo evidence for the standalone antimicrobial function of CpG-ODN in chicks against Escherichia coli and Salmonella infections using in ovo (embryo injection)4,5, intramuscular and subcutaneous6,7 routes of delivery. CpG-ODNs are short, single-stranded DNA that can ...
Interestingly, the combined CD1d immunotherapy and peptide/CpG-ODN immunization resulted in a synergistic effect on the expansion of NK cells with a threefold in- creased frequency at day 7 in the spleen (Figure 2B, right), while peptide/CpG-ODN vaccine alone had no effect on NK cells. The...
The Freund's adjuvant used in this study was purchased from the Sigma (St. Louis, MO, USA). CpG-ODN Adjuvant A CpG-enriched pUC18 plasmid containing 20 copies of CpG-ODN 2006 (sequence: 5′-TCGTCGTTTTGTCGTTTTGTCGTTTTGTCGTTTTGTCGTT-3′) was generated by tandem insertion of four copies...