The study medication had to be discontinued in 2 patients in the indomethacin group, due to dyspepsia. INTERPRETATION: After short-term administration, the selective COX-2 inhibitor rofecoxib was effective in preventing heterotopic ossification after total hip arthroplasty....
一些现有的 NSAIDS, 低剂量时对COX2优先抑制, 称为倾向性COX-2抑制剂 (referential COX-2 inhibitor),如美洛昔康(meloxicam)、尼美舒利(nimesulide)、依托 度酸(etodolac)。此类药物的临床疗效与非选择性COX抑制剂相当,但胃肠 道不良反应发生率较低。特异性COX-2抑制剂 (specific COX-2 inhibitor), 如塞莱...
specific cox-2 inhibitor has significant advantages, in gastrointestinal safety but the safety of the medication for a long time still need further research and evaluation. 1. 环氧化酶简介 1.1 环氧化酶的结构 1994年Picot等用X射线晶体衍射学方法揭示了 COX的三维结构,证实 C0X在 ...
8、erday (meloxicam), beauty and ShuLi (nimesulide), depending on the degree of acid (etodolac). Such drugs the clinical curative effect of nonselective COX inhibitors, but the incidence of gastrointestinal adverse reaction is low. Specific cox-2 inhibitor (specific cox-2 inhibitor), like Mr...
The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med. 2001;345:433-442. Vioxx? (rofecoxib). US product information. Merck Co., Inc. 2000. 与NSAIDs一样,COX-2抑制剂也能够升高某些患者的血压,引起 心血管不了反应。因此,在开处方时,需要提醒患者,尤其对高危 患者(如老年和脱水患者...
Food and Drug Admi-nistration (FDA) advisory panel voted to approve celecoxib (Celebrex), the first selective cyclooxy-genase (COX)-2 inhibitor, for treating arthritis pain [1]. Rofecoxib (Vioxx) was approved several months later [2], and other selective COX-2 inhibitors are expected to ...
2 inhibitors are known to influence the immune system in a way that may redirect this imbalance. Based on these suggestions, the COX-2 inhibitor celecoxib has been tested as a possible adjunctive therapeutic approach in the treatment of schizophrenia. While the first trial using celecoxib as add...
Selective cyclo-oxygenase-2 (COX-2) inhibitors and non-steroidal anti-inflammatory medications (NSAIDs) may have a role in the management of FOP symptoms. 选择性环氧化酶2抑制剂 (COX-2) 和非甾体类抗炎药(NSAID) 可能在FOP的症状管理中起作用。
Efficacy and tolerability of lumiracoxib, a highly selective cyclo-oxygenase-2 (COX2) inhibitor, in the management of pain and osteoarthritis Lumiracoxib is a COX2 inhibitor that is highly selective, is more effective than placebo on pain in osteoarthritis (OA), with similar analgesic and anti-...
NSAID alone (6.0% vs 3.1%) The two comparator arms (diclofenac and ibuprofen) have relatively weak antiplatelet effects JAMA 2000; 284:1247-55 Pooled Analyses of COX-2 Selective Agents Mukherjee et al (JAMA 2001) Compared MI rates from RCT’s (including VIGOR and CLASS) with 23,407 ...