COX-2 inhibitorsinflammationCyclooxygenase (prostaglandin G/H-synthase, COX) exists in two isoforms which have been termed COX-1 (constitutive enzyme) and COX-2 (an inducible enzyme) 1,2 . COX-1 has been cloned from a number of sources including man, the mouse and sheep 3–7 . COX-2 ...
Cox-2-selective inhibitors: the new super aspirins. Mol Pharmacol. 1999 Apr;55(4):625-31. Research Support, U.S. Gov't, P.H.S.; Review David L DeWitt - 《Molecular Pharmacology》 被引量: 572发表: 1999年 Renal effects of COX-2-selective inhibitors. Although nonsteroidal anti-inflammato...
There has been demonstrated the role of the COX-2 blockers in risk decrease of four most common malignant tumors: breast cancer (by 71%), prostate cancer (by 55%), colon cancer (by 70%) and lung cancer (by 79%). The role of COX-2 inhibitors in the prevention of developing ...
SelectiveCOX-2inhibitorsmodulatecellularsenescenceinhumandermal fibroblastsinacatalyticactivity-independentmanner SoRaKim a ,JungHaePark a ,MiEunLee a ,JeongSooPark b ,SangChulPark c, **,JeongA.Han a, * a DepartmentofBiochemistryandMolecularBiology,KangwonNationalUniversityCollegeofMedicine,Chuncheon200-...
Cox-2-selective inhibitors: the new super aspirins. 来自 Semantic Scholar 喜欢 0 阅读量: 31 作者: David L DeWitt 摘要: Mol Pharmacol. 1999 Apr;55(4):625-31. Research Support, U.S. Gov't, P.H.S.; Review 关键词: Humans Aspirin Isoenzymes Anti-Inflammatory Agents, Non-Steroidal ...
The reason for the imbalance between PGI2 and TAX2 doctrine has been widely accepted. In recent years, studies have shown that selective COX-2 inhibitors has many other new roles and side effects, there is a great need for doing a new judgement on the role of selective COX-2 inhibitors....
There is a greater body of evidence supporting the relative cardiovascular safety of celecoxib when used at the doses recommended for the treatment of arthritis than for any of the other selective COX-2 inhibitors or NSAIDs. 展开 关键词: COX-2 inhibitors NSAIDs myocardial infarction cardiovascular...
In vitro assays were conducted and structural modifications were carried out on these scaffolds to furnish compound 16 which exhibited effective COX-2 inhibitory activity, with IC50 values of 0.409 µM and an excellent selectivity versus COX-1. Radiolabeling of this most potent derivative [18F...
aCost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis l 考克斯的成本效益单独2种有选择性的抗化剂和传统NSAIDs或与一种氢核泵浦抗化剂的组合为人以骨关节炎l[translate]...
There is no significant change in clotting time, heart rate, systolic & diastolic blood pressure & also ECG.Conclusion: Selective COX-2 inhibitors also have shown significant changes in bleeding time, like that of non-selective NSAIDs, when used for a short-term treatment.Keywords: Adverse drug...