Core fucosylation is required for midline patterning during zebrafish development. Dev Dyn. 2010; 239: 3380-90.Seth A, Machingo QJ, Fritz A, Shur BD. Core fucosylation is required for midline patterning during zebrafish development. Dev Dyn. 2010; 239 :3380–3390. doi...
Aberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis. Here we find that multiple viral envelope proteins,
Core fucosylation regulates epider- mal growth factor receptor-mediated intracellular signaling. Journal of Biological Chemistry 2006;281(5):2572-7.Wang X, Gu J, Ihara H, Miyoshi E, Honke K, Taniguchi N (2006) Core fucosylation regulates epidermal growth factor receptor-mediated intracellular ...
used to analyze the expression of CD36 in pericyte during AKI-CKD; IRI to conduct AKI-CKD mouse model; Hypoxia/Reoxygenation (H/R) to induce the cell model; RT-qPCR and Western blotting to detect gene expression; IP and confocal-IF to determine the core fucosylation (CF) level of CD36...
Core fucosylation of N-linked glycoproteins has been linked to the functions of glycoproteins in physiological and pathological processes. However, quantitative characterization of core fucosylation remains challenging due to the complexity and heterogen
transition in RIF. The down-regulation of core fucosylation prevented the pericyte transition and RIF by inhibiting the activities of both the TGF-β/Smad and PDGF/ERK pathways. This study is the first to suggest that the core fucosylation of pericytes represents a promising “hub” target for ...
Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells. et al. Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells. Cancer Sci. 2009; 100 (5):888–895. doi: ... D Osumi,M Takahashi,E Miyoshi,... - 《...
Mechanistically, RACK1 increased the expression of FUT8 by inhibiting miR-1275, which in turn promoted the FUT8-catalyzed core-fucosylation of cystine/glutamate antiporter SLC7A11, thereby inhibiting SLC7A11 degradation and cell ferroptosis. Our data highlight the role of RACK1 in cervical cancer ...
No other glycosyltransferase has been found to be equipped with this domain, suggesting that the SH3 domain in FUT8 specifically regulates FUT8 functions, such as core fucosylation activity, subcellular localization, and/or interaction with other molecules. In this study, by using mutant FUT8 ...
Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for signaling receptors involved in many physiological and pathological processes such as cell growth,